Otto, Carolin
Mayo Clinic
Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Citations 2
HLA Associations Differ by Ethnicity and Aquaporin-4 Antibody Status in Patients With Neuromyelitis Optica Spectrum Disorders
Niederschweiberer, Moritz , Fernández-Viña, Marcelo , Montero-Martín, Gonzalo , Osoegawa, Kazutoyo , Behne, Megan , Franke, André , Jarius, Sven , Wildemann, Brigitte , Schindler, Patrick , Paul, Friedemann , Oksenberg, Jorge R. , Ruprecht, Klemens , Behne, Jacinta M., Han, May H., Riley, Claire S., Osoegawa, Kazutoyo , Behne, Megan , Franke, André , Lieb, Wolfgang , Jarius, Sven , Wildemann, Brigitte , Schindler, Patrick , Otto, Carolin , Paul, Friedemann , Flanagan, E P , Cook, Lawrence J , Oksenberg, Jorge , Yeaman, Michael R , Ruprecht, Klemens , Niederschweiberer, Moritz A , Panagiotaropoulou, Georgia , Otto, Carolin , Flanagan, Eoin P. , Cook, Lawrence J. , Ripke, Stephan , Bennett, Jeffrey L. , Kister, Ilya , Levy, Michael , Planchon, Sarah M. , Repovic, Pavle , Smith, Terry J. , Traboulsee, Anthony
Neurology Neuroimmunology & Neuroinflammation | April 16, 2026 | Volume: 13 | Issue: 3 | Pages: No page available
Multiple SclerosisIs Rare in Epstein–Barr Virus–Seronegative Children withCentral Nervous SystemInflammatory Demyelination
Nourbakhsh, Bardia , Cordano, Christian , Asteggiano, Carlo , Ruprecht, Klemens , Otto, Carolin , Lui, Allysa, Hart, Janace, Waubant, Emmanuelle L. , Otto, Carolin , Rutatangwa, Alice , Flanagan, Eoin P. , James, Judith A.
Annals of Neurology | March 11, 2021 | Volume: 89 | Issue: 6 | Pages: 1234-1239
Although Epstein–Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diagnosis of MS were reported to be EBV‐seronegative. When re‐evaluating 25 EBV‐seronegative children out of 189 pediatric patients with a diagnosis of clinically isolated syndrome/MS, we found anti–myelin oligodendrocyte glycoprotein (MOG) antibody in 11 of 25 (44%) EBV‐seronegative but only 9 of 164 (5.5%,p < 0.001) EBV‐seropositive patients. After critical review, MS remained a plausible diagnosis in only 4 of 14 EBV‐seronegative/MOG antibody–negative patients. In children with an MS‐like presentation, EBV seronegativity should alert clinicians to consider diagnoses other than MS, especially MOG‐antibody disease. ANN NEUROL 2021;89:1234–1239