Cordano, Christian

Mayo Clinic

University of California, San Francisco

Multiple SclerosisIs Rare in Epstein–Barr Virus–Seronegative Children withCentral Nervous SystemInflammatory Demyelination

Nourbakhsh, Bardia , Cordano, Christian , Asteggiano, Carlo , Ruprecht, Klemens , Otto, Carolin , Lui, Allysa, Hart, Janace, Waubant, Emmanuelle L. , Otto, Carolin , Rutatangwa, Alice , Flanagan, Eoin P. , James, Judith A.

Annals of Neurology | March 11, 2021 | Volume: 89 | Issue: 6 | Pages: 1234-1239

Although Epstein–Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diagnosis of MS were reported to be EBV‐seronegative. When re‐evaluating 25 EBV‐seronegative children out of 189 pediatric patients with a diagnosis of clinically isolated syndrome/MS, we found anti–myelin oligodendrocyte glycoprotein (MOG) antibody in 11 of 25 (44%) EBV‐seronegative but only 9 of 164 (5.5%,p < 0.001) EBV‐seropositive patients. After critical review, MS remained a plausible diagnosis in only 4 of 14 EBV‐seronegative/MOG antibody–negative patients. In children with an MS‐like presentation, EBV seronegativity should alert clinicians to consider diagnoses other than MS, especially MOG‐antibody disease. ANN NEUROL 2021;89:1234–1239

Cordano, Christian

Citations 1

Multiple SclerosisIs Rare in Epstein–Barr Virus–Seronegative Children withCentral Nervous SystemInflammatory Demyelination

Nourbakhsh, Bardia , Cordano, Christian , Asteggiano, Carlo , Ruprecht, Klemens , Otto, Carolin , Lui, Allysa, Hart, Janace, Waubant, Emmanuelle L. , Otto, Carolin , Rutatangwa, Alice , Flanagan, Eoin P. , James, Judith A.