Moreira, Alvaro
Mayo Clinic
Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Citations 1
Quantitative proteomics links mitochondrial dysfunction to metabolic changes and epithelial differentiation defects in hyperoxia-exposed neonatal airway cells
Ganguly, Abhrajit , Carter, Cynthia, Negron, Aristides Rivera, Moreira, Alvaro , Walters, Matthew S. , Prakash, Y. S. , Tipple, Trent E. , Richardson, Arlan, Moreira, Alvaro , Walters, Matthew S , Prakash, Y S , Tipple, Trent E , Zhong, Hua , Rogers, Lynette Kay
American Journal of Physiology-Lung Cellular and Molecular Physiology | December 5, 2025 | Volume: 330 | Issue: 1 | Pages: L87-L103
We report that moderate hyperoxia during a critical window of mucociliary differentiation disrupts terminal maturation in neonatal airway epithelial cells cultured in a three-dimensional model. Hyperoxia induces mitochondrial bioenergetic dysfunction and metabolic reprogramming, with proteomic analysis identifying complex I disruption as a key driver of impaired differentiation. Overall, these findings reveal a previously underrecognized link between mitochondrial bioenergetics and airway epithelial development, positioning metabolic dysfunction as an early trigger of hyperoxia-induced neonatal airway injury.