Makino, Ayako
Mayo Clinic
Department of Medicine, University of California, San Diego, La Jolla, California, United States.
Citations 1
Store-operated Ca 2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells
Babicheva, Aleksandra , Elmadbouh, Ibrahim , Song, Shanshan , Thompson, Michael A, Powers, Ryan, Jain, Pritesh, Izadi, Amin , Chen, Jiyuan , Yung, Lauren, Parmisano, Sophia , Paquin, Cole, Wang, Ting , Shyy, John Y.-J. , Thistlethwaite, Patricia A. , Makino, Ayako , Yuan, Jason X.‐J. , Shyy, John Y-J , Makino, Ayako , Prakash, Y S , Pabelick, Christina M , Yuan, Jason X-J , Babicheva, Aleksandra , Izadi, Amin, Wang, Wei‐Ting , Chen, Yuqin , Alotaibi, Mona , Shyy, John Y.-J., Wang, Jian , Prakash, Y. S. , Pabelick, Christina M.
American Journal of Physiology-Lung Cellular and Molecular Physiology | May 7, 2025 | Volume: 328 | Issue: 6 | Pages: L844-L857
EndMT has been reported to contribute to the pathogenesis of PAH. In this study, we aimed to determine the role of Ca 2+ signaling in the development of EndMT in human lung vascular endothelial cells. Our data suggest that TGF-β 1 requires store-operated Ca 2+ entry through STIM1/Orai channels to induce SNAI-mediated EndMT. For the first time, we demonstrated that TGF-β 1 -induced EndMT is a Ca 2+ -dependent event, whereas inhibition of STIM1/Orai interaction attenuated EndMT in response to TGF-β 1 .