Herrmann, Sandra
Mayo Clinic
Nephrology and Hypertension, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Citations 2
Renovascular disease induces functionally relevant, locus-specific alterations to DNA methylation and hydroxymethylation in swine scattered tubular-like cells
Iyer, Vinaya C., Shivam, Kumar, Kazeminia, Sara , Zhu, Xiang-Yang, Tang, Hui, Xue, Ailing, Chade, Alejandro , Lerman, Lilach O. , Herrmann, Sandra, Irazabal, Maria V , Lerman, Lilach O , Eirin, Alfonso , Kazeminia, Sara , Herrmann, Sandra M. , Irazabal, María V. , Eirin, Alfonso
American Journal of Physiology-Renal Physiology | July 2, 2026 | Volume: 331 | Issue: 2 | Pages: F213-F224
Scattered tubular-like cells (STCs) are dedifferentiated renal tubular cells that repair other damaged kidney cells. This study shows that renovascular disease (RVD) induces site-specific 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications in DNA associated with transcriptional changes and impaired proliferative capacity of swine STCs, which could be mitigated in RVD-STCs treated with an epigenetic modulator. Therefore, our observations may contribute to the development of novel approaches to preserve the reparative capacity of STCs in individuals with RVD.
Sunitinib induced glomerular thrombotic microangiopathy in a patient with refractory pancreatic neuroendocrine tumour
Khan, Aisha , Gangelhoff, Margarita Consing, Moubarak, Simon , Nooruddin, Karim, Alexander, Mariam P., Alexander, Mariam P. , Herrmann, Sandra, Alexander, Mariam P , Herrmann, Sandra M.
Journal of Clinical Pathology | December 14, 2024 | Volume: 78 | Issue: 5 | Pages: 357-358