Citations 1
Renovascular disease induces functionally relevant, locus-specific alterations to DNA methylation and hydroxymethylation in swine scattered tubular-like cells
Iyer, Vinaya C., Shivam, Kumar, Kazeminia, Sara , Zhu, Xiang-Yang, Tang, Hui, Xue, Ailing, Chade, Alejandro , Lerman, Lilach O. , Herrmann, Sandra, Irazabal, Maria V , Lerman, Lilach O , Eirin, Alfonso , Kazeminia, Sara , Herrmann, Sandra M. , Irazabal, María V. , Eirin, Alfonso
American Journal of Physiology-Renal Physiology | July 2, 2026 | Volume: 331 | Issue: 2 | Pages: F213-F224
Scattered tubular-like cells (STCs) are dedifferentiated renal tubular cells that repair other damaged kidney cells. This study shows that renovascular disease (RVD) induces site-specific 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications in DNA associated with transcriptional changes and impaired proliferative capacity of swine STCs, which could be mitigated in RVD-STCs treated with an epigenetic modulator. Therefore, our observations may contribute to the development of novel approaches to preserve the reparative capacity of STCs in individuals with RVD.