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Perry, William R

0000-0001-8718-8306

Mayo Clinic

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.

Citations 32

Comparison of Open, Laparoscopic, and Robotic Approaches for Hartmann’s Reversal: The Mayo Clinic Experience
Ferrari, Davide , Peponis, Thomas , Violante, Tommaso , Glasgow, Amy E. , Perry, William , Perry, William , Violante, Tommaso , Perry, William R , Ferrari, Davide , Larson, David W. , Behm, Kevin T.

Diseases of the Colon & Rectum | December 8, 2025 | Volume: 69 | Issue: 3 | Pages: 432-441

10.1097/dcr.0000000000004066 Get It

BACKGROUND: End colostomy reversal with colorectal anastomosis (Hartmann’s reversal) is a technically challenging procedure associated with significant morbidity due to adhesions and distorted anatomy after the index surgery. OBJECTIVE: To compare perioperative outcomes of open, laparoscopic, and robotic approaches for Hartmann’s reversal. DESIGN: Retrospective analysis of prospectively maintained data. SETTINGS: High-volume tertiary referral center with specialized colorectal surgery expertise. PATIENTS: A total of 218 patients who underwent Hartmann’s reversal between May 2018 and April 2023. MAIN OUTCOME MEASURES: Primary outcomes included hospital length of stay and rate of conversion. Secondary outcomes included overall complication rates and time to return of bowel function. RESULTS: Of 218 patients, 139 (63.8%) underwent open surgery, 48 (22.0%) underwent laparoscopic surgery, and 31 (14.2%) underwent robotic surgery. Robotic surgery had the lowest estimated blood loss (median 77.5 vs 100 mL laparoscopic and 150 mL open, p < 0.0001). Conversion to open surgery occurred in 16.1% of robotic cases compared with 35.4% of laparoscopic cases ( p = 0.0618). Minimally invasive approaches were associated with shorter hospital length of stay (median 3.0 vs 4.0 days, p < 0.0001) and faster return of bowel function (median 2.0 vs 3.0 days, p = 0.0095) compared to open surgery. Overall 30-day morbidity was 23.4%, with no significant difference among approaches ( p = 0.30). The temporal trend showed increasing adoption of robotic techniques, from 0% in 2018 to 53.8% in 2023, and a decrease in the proportion of cases approached by open surgery, from 76.9% in 2018 to 23.1% in 2023. LIMITATIONS: Retrospective design and single-institution experience with limited follow-up duration. CONCLUSIONS: Minimally invasive approaches to Hartmann’s reversal are associated with improved short-term outcomes compared to open surgery. The robotic approach shows promise in reducing conversion rates, potentially extending the benefits of minimally invasive surgery to more patients undergoing this challenging procedure. See Video Abstract . COMPARACIÓN DE LOS ENFOQUES ABIERTO, LAPAROSCÓPICO Y ROBÓTICO PARA LA REVERSIÓN DE HARTMANN: LA EXPERIENCIA DE LA CLÍNICA MAYO ANTECEDENTES: La reversión de la colostomía terminal con anastomosis colorrectal (reversión de Hartmann) es un procedimiento técnicamente complejo asociado a una morbilidad significativa debido a las adherencias y la distorsión anatómica tras la cirugía inicial. OBJETIVO: Comparar los resultados perioperatorios de los abordajes abiertos, laparoscópicos y robóticos para la reversión de Hartmann. DISEÑO: Análisis retrospectivo de datos mantenidos prospectivamente. ENTORNO: Centro terciario de referencia de gran volumen con experiencia especializada en cirugía colorrectal. PACIENTES: Un total de 218 se sometieron a la reversión de Hartmann entre mayo de 2018 y abril de 2023. PRINCIPALES MEDIDAS DE RESULTADOS: Los resultados primarios incluyeron la duración de la estancia hospitalaria y la tasa de conversión. Los resultados secundarios incluyeron las tasas generales de complicaciones y el tiempo de recuperación de la función intestinal. RESULTADOS: De los 218 pacientes, 139 (63,8 %) se sometieron a cirugía abierta, 48 (22,0 %) a cirugía laparoscópica y 31 (14,2 %) a cirugía robótica. La cirugía robótica tuvo la menor pérdida de sangre estimada (mediana, 77,5 ml frente a 100 ml en laparoscopia y 150 ml en cirugía abierta, p < 0,0001). La conversión a cirugía abierta se produjo en el 16,1 % de los casos robóticos frente al 35,4 % de los casos laparoscópicos ( p = 0,0618). Los abordajes mínimamente invasivos se asociaron con una estancia hospitalaria más corta (mediana de 3,0 días frente a 4,0 días, p < 0,0001) y un retorno más rápido de la función intestinal (mediana de 2,0 días frente a 3,0 días, p = 0,0095) en comparación con la cirugía abierta. La morbilidad global a los 30 días fue del 23,4 %, sin diferencias significativas entre los distintos enfoques ( p = 0,30). La tendencia temporal mostró un aumento en la adopción de técnicas robóticas, del 0 % en 2018 al 53,8 % en 2023, y una disminución en la proporción de casos abordados mediante cirugía abierta, del 76,9 % en 2018 al 23,1 % en 2023. LIMITACIONES: Diseño retrospectivo y experiencia de una sola institución con una duración de seguimiento limitada. CONCLUSIONES: Los enfoques mínimamente invasivos para la reversión de Hartmann se asocian con mejores resultados a corto plazo en comparación con la cirugía abierta. El enfoque robótico es prometedor para reducir las tasas de conversión, lo que podría ampliar los beneficios de la cirugía mínimamente invasiva a más pacientes que se someten a este procedimiento tan complejo. ( AI-generated translation ).
Hyperbaric Oxygen Therapy in the Management of Refractory Perianal Crohn’s Disease
Hajjar, Roy , Bews, Katherine A. , Khan, Sidrah , Gleason, Lauren, Sánchez, Emilio , Reynolds, Ian S. , Kane, Sunanda V. , Perry, William , Mathis, Kellie L. , Alaoui, Ahmed Amine , Reynolds, Ian S , Perry, William R , McKenna, Nicholas P.

Journal of Clinical Medicine | September 29, 2025 | Volume: 14 | Issue: 19 | Pages: 6843

10.3390/jcm14196843 Get It

Background: Crohn’s disease (CD) is an inflammatory bowel disease (IBD) that is prevalent worldwide. It can affect any segment of the gastrointestinal tract, from the mouth to the anus. When CD affects the anus, perianal fistulizing disease develops. The management of perianal CD is challenging and may require morbid surgery when there is no response to medical therapy. The emergence of novel biologic therapies, namely tumor necrosis alpha (TNF-α) inhibitors, has proven to provide long-term relief and prevent disease-related complications. Perianal CD is, however, refractory or recurrent in up to 80% of patients. One of the reported options to manage perianal CD is hyperbaric oxygen therapy (HBOT), which aims at increasing tissue oxygen saturation in an attempt to promote repair and reverse local inflammation. Data on this approach is scant. Methods: A retrospective review was performed to identify patients with CD at the Mayo Clinic in Rochester who underwent HBOT for perianal disease between 2014 and 2023. Demographic and clinical data were reviewed, including the history of the disease, concomitant medical and surgical therapy and the need for fecal diversion. The HBOT regimen, including the number of sessions and clinical response, were reviewed. Results: Six patients aged from 19 to 60 years underwent HBOT for perianal CD. Two patients had a history of total proctocolectomy with ileal-anal pouch anastomosis (IPAA). All patients except one were on immunosuppressive medication including biologic agents. Four patients had fecal diversion with an ileostomy or colostomy. Patients received between 10 and 40 sessions of HBOT. Four patients reported symptomatic improvement. On physical examination and/or imaging assessment, improvement was noted in one patient. Progression of the perianal disease was noted in all other patients, with all except one requiring an operation in the following year. Conclusions: HBOT may provide symptomatic relief in some patients with refractory perianal CD, but data on its long-term efficacy remains limited.
Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports
Tamm, Andres , Jones, Helen , Doshi, Neel , Perry, William , Withers, Joshua, Salih, Hizni , Noble, Theresa , Little, Stephanie , Roadknight, Gail , Campell, D.J., Matharu, Sheila, Teare, Marion, Galdikas, A., Papadimitriou, Dimitri , Scanlon, Lauren , Woods, Kerrie , Cunningham, Chris , Roadknight, Gail , Perry, William R , Várnai, Kinga A. , Matharu, Sheila, Starling, Naureen , Teare, Marion, Galdikas, Algirdas, Glampson, Ben , Mercuri, Luca , Wasan, Harpreet , Malcomson, Lee , O’Hara, Catherine M. , Renehan, Andrew G. , Nicholson, Brian D , Davies, Jim , Morris, Eva J.A. , Cunningham, Chris

BMJ Health & Care Informatics | September 22, 2025 | Volume: 32 | Issue: 1 | Pages: e101521

10.1136/bmjhci-2025-101521 Get It

Objectives The ‘tumour, node, metastasis’ (TNM) classification of colorectal cancer (CRC) predicts prognosis and so is vital to consider in analyses of patterns and outcomes of care when using electronic health records. Unfortunately, it is often only available in free-text reports. This study aimed to develop regex-based text-processing algorithms that identify the reports describing CRC and extract the TNM staging at a low computational cost. Methods The CRC and TNM extraction algorithms were iteratively developed using 58 634 imaging and pathology reports of patients with CRC from the Oxford University Hospitals (OUH) and Royal Marsden (RMH) NHS Foundation Trusts (FT), with additional input from Imperial College Healthcare and Christie NHS FTs. The algorithms were evaluated on a stratified random sample of 400 OUH development data reports and 400 newer ‘unseen’ OUH reports. The reports were annotated with the help of two clinicians. Results The CRC algorithm achieved at least 93.0% positive predictive value (PPV), 72.1% sensitivity, 64.0% negative predictive value (NPV) and 90.1% specificity for primary CRC on pathology reports. On imaging reports, it demonstrated at least 78.0% PPV, 91.8% sensitivity, 93.0% NPV and 80.9% specificity. For the main T/N/M categories, the TNM algorithm achieved PPVs of at least 93.9% (T), 97.7% (N) and 97.2% (M), and sensitivities of 63.6% (T), 89.6% (N) and 64.8% (M). NPVs were at least 45.0% (T), 91.1% (N), 88.4% (M), and specificities 95.7% (T), 98.1% (N), 99.3% (M). Reductions in performance were mostly due to implicit staging. For extracting explicit TNM stages, current or historical, the algorithm made no errors on 400 pathology reports and six errors on 400 imaging reports. Conclusion The TNM algorithm accurately extracts explicit TNM staging, but other methods are needed for retrieving implicit stages. The CRC algorithm is accurate on non-supplementary reports, but outputs need additional review if higher precision is required.
Safety of Hemorrhoid Procedures in Patients Who Are Immunocompromised: The Mayo Clinic Experience
Hajjar, Roy , Bews, Katherine A. , Reynolds, Ian S. , Khan, Sidrah , Gleason, Lauren, Sánchez, Emilio , Perry, William , Mathis, Kellie L. , Gleason, Lauren T, McKenna, Nicholas P , Perry, William R , Reynolds, Ian S , McKenna, Nicholas P.

Diseases of the Colon & Rectum | August 14, 2025 | Volume: 68 | Issue: 11 | Pages: 1338-1343

10.1097/dcr.0000000000003939 Get It

BACKGROUND: Hemorrhoidal disease and immunosuppression are prevalent. Management of hemorrhoidal disease in this patient population is challenging. Most societies recommend conservative management due to the presumed risks of morbid complications, including sepsis and impaired healing. Data on the risks of office-based and operative procedures in immunocompromised patients are scant. OBJECTIVE: To evaluate postoperative outcomes after both office-based procedures and operative intervention for hemorrhoidal disease in immunocompromised patients. DESIGN: Retrospective medical record review. SETTINGS: Single-center, tertiary referral center. PATIENTS: Adult patients were included who had hemorrhoidal disease and primarily medication-induced immunosuppression and were undergoing an office-based procedure or operative intervention for hemorrhoidal disease while on immunosuppression at Mayo Clinic in Rochester between 2010 and 2023. MAIN OUTCOME MEASURES: The primary outcome was the development of infectious complications or wound complications. RESULTS: Fifty-five immunocompromised patients, with a median age of 60 years, underwent a total of 68 hemorrhoidal procedures during the study time frame. All patients had immunosuppression induced by medication, except for 1 patient with bone marrow failure syndrome. The most common reason for immunosuppression was rheumatoid arthritis, followed by prior kidney transplant. The most common medications were chronic corticosteroids and methotrexate in more than one-third of patients each. Of 68 total interventions, hemorrhoidectomy (32%) and excision of a thrombosed hemorrhoid (26%) were the 2 most common operations performed. Sixteen adverse events were reported in 14 patients (25%). Three cases of postoperative cellulitis were documented after thrombosed external hemorrhoid excision, hemorrhoidopexy, and Whitehead hemorrhoidectomy. No postoperative intravenous antibiotics were administered. No cases of pelvic sepsis were documented. LIMITATIONS: The retrospective nature of the study and the heterogeneity of the study population. CONCLUSIONS: These data suggest that office-based and surgical procedures are safe and feasible in patients with immunosuppression. See Video Abstract . SEGURIDAD DE LOS PROCEDIMIENTOS PARA EL TRATAMIENTO DE HEMORROIDES EN PACIENTES INMUNODEPRIMIDOS: LA EXPERIENCIA DE LA CLÍNICA MAYO ANTECEDENTES: La enfermedad hemorroidal y la inmunosupresión son prevalentes. El tratamiento de la enfermedad hemorroidal en esta población de pacientes es difícil. La mayoría de las sociedades recomiendan un tratamiento conservador debido a los riesgos presuntos de complicaciones mórbidas, como sepsis y alteración de la cicatrización. Los datos sobre los riesgos de los procedimientos ambulatorios y quirúrgicos en pacientes inmunodeprimidos son escasos. OBJETIVO: Evaluar los resultados posoperatorios tras procedimientos ambulatorios y cirugía para la enfermedad hemorroidal en pacientes inmunodeprimidos. DISEÑO: Revisión retrospectiva de historias clínicas. ENTORNO: Centro terciario de referencia único. PACIENTES: Pacientes adultos con enfermedad hemorroidal e inmunosupresión inducida principalmente por medicamentos que se sometieron a un procedimiento ambulatorio o a una intervención quirúrgica para la enfermedad hemorroidal mientras estaban en tratamiento inmunosupresor en la Clínica Mayo de Rochester entre 2010 y 2023. PPRINCIPALES MEDIDAS DE RESULTADO: El resultado principal fue la aparición de complicaciones infecciosas o complicaciones de la herida. RESULTADOS: Cincuenta y cinco pacientes inmunodeprimidos, con una mediana de edad de 60 años, se sometieron a un total de 68 procedimientos hemorroidales durante el periodo de estudio. Todos los pacientes presentaban inmunosupresión inducida por medicación, excepto uno con síndrome de insuficiencia medular. La causa más frecuente de inmunosupresión fue la artritis reumatoide, seguida de un trasplante renal previo. Los medicamentos más frecuentes fueron los corticosteroides crónicos y el metotrexato, en más de un tercio de los pacientes. De las 68 intervenciones totales, la hemorroidectomía (32 %) y la extirpación de una hemorroide trombosada (26 %) fueron las dos operaciones más comunes realizadas. Se notificaron 16 eventos adversos en 14 (25 %) pacientes. Se documentaron tres casos de celulitis posoperatoria tras la extirpación de una hemorroide externa trombosada, una hemorroidopexia y una hemorroidectomía de Whitehead. No se administraron antibióticos intravenosos postoperatorios. No se documentaron casos de sepsis pélvica. LIMITACIONES: El carácter retrospectivo del estudio y la heterogeneidad de la población estudiada. CONCLUSIONES: Estos datos sugieren que los procedimientos ambulatorios y quirúrgicos son seguros y viables en pacientes con inmunosupresión. (AI-generated translation )
Super Learner Enhances Postoperative Complication Prediction in Colorectal Surgery
Violante, Tommaso , Novelli, Marco , Perry, William , Mathis, Kellie L. , Dozois, Eric J. , Violante, Tommaso , Perry, William R , Ferrari, Davide , Larson, David W.

Annals of Surgery | July 23, 2025 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1097/sla.0000000000006847 Get It

Objective: To determine if a Super Learner (SL) machine learning approach could improve the predictive accuracy of the American College of Surgeons Risk Calculator (ACS-RC) for postoperative complications in patients undergoing colorectal surgery. Summary of Background Data: Machine learning (ML) has shown significant potential to advance medical fields, including surgical risk prediction. Current tools, like the ACS-RC which uses logistic regression and extreme gradient boosting, are standard but may be enhanced by more advanced ML ensembles. Methods: This retrospective study analyzed colorectal surgery cases from the 2018-2022 ACS National Surgical Quality Improvement Program (NSQIP) database. An SL model, which combines multiple ML algorithms, was developed to predict fourteen postoperative outcomes. Its performance was compared against traditional logistic regression (LOG) and extreme gradient boosting (XGB) models. Key performance metrics included discrimination (AUROC, AUPRC) and calibration (Brier score, Hosmer-Lemeshow test). Results: The SL model demonstrated superior performance across all predicted complications when compared to both LOG and XGB. It showed superior discrimination for severe outcomes, achieving an AUROC greater than 0.94 for predicting mortality. The SL model was also more accurate in predicting infectious complications and length of stay, and its calibration metrics indicated a better overall fit and accuracy. Conclusions: The Super Learner model enhances the accuracy of postoperative risk prediction in colorectal surgery. Its superior performance suggests it is a promising tool for improving personalized patient counseling, aiding clinical decision-making, and optimizing resource allocation.
Reevaluating Preoperative Type and Screen: Identifying When It Is Necessary for Elective Colorectal Surgery
Khan, Sidrah , Glasgow, Amy E. , Hajjar, Roy , Reynolds, Ian S. , Gleason, Lauren, Sanchez, Emilo, Perry, William , Mathis, Kellie L. , Glasgow, Amy, Gleason, Lauren T, Perry, William R , Reynolds, Ian S , Sanchez, Emilo, McKenna, Nicholas P.

Diseases of the Colon & Rectum | June 10, 2025 | Volume: 68 | Issue: 9 | Pages: 1093-1099

10.1097/dcr.0000000000003844 Get It

BACKGROUND: Rising health care costs necessitate a reassessment of routine preoperative practices. Despite low transfusion rates in elective colorectal operations, many hospitals continue to perform routine preoperative type and screen testing. OBJECTIVE: To assess perioperative blood transfusion rates and determine preoperative and surgical factors associated with transfusions to determine whether the routine preoperative type and screen testing are necessary for elective abdominal colorectal surgeries, particularly in the setting of minimally invasive surgery. DESIGN: Retrospective cohort study. SETTINGS: Mayo Clinic, 2019–2023. PATIENTS: Adult patients undergoing elective abdominal colorectal operations. Exclusion criteria included emergent operations and nonabdominal procedures. INTERVENTIONS: None. MAIN OUTCOME MEASURES: The primary outcome was the incidence of intraoperative and immediate postoperative (≤72 hours) blood product transfusion. Secondary outcomes assessed associations between transfusion rates, surgical approach, and preoperative variables. RESULTS: Among 4652 patients, 2770 underwent minimally invasive surgery and 1882 underwent open procedures. Perioperative red blood cell transfusion rates were lower in minimally invasive procedures (3.0% colectomy, 4.5% proctectomy) compared to open procedures (8.7% colectomy, 21.5% proctectomy). Open proctectomy was the strongest predictor of transfusion (OR 12.05; 95% CI, 8.94–16.26; p < 0.0001) followed by open colectomy (OR 2.59; 95% CI, 2.04–3.30; p < 0.0001). Preoperative factors including ASA class IV (OR 5.21; 95% CI, 1.09–24.82; p < 0.0382) and anemia (OR 4.14; 95% CI, 3.09–5.55; p < 0.0001) were also significantly associated with red blood cell transfusion. LIMITATIONS: The retrospective nature of the study may introduce selection bias. In addition, institutional practice patterns may limit the generalizability of findings. CONCLUSIONS: Patients undergoing elective minimally invasive colorectal surgery have very low rates of perioperative blood transfusions; thus, routine preoperative type and screen testing is likely unnecessary for this patient cohort. However, patients undergoing planned open operations, likely due to procedural complexity, and those who are ASA class IV, have preoperative anemia, or have anal cancer have higher transfusion risks and may benefit from selective testing. Implementing a risk-stratified approach based on surgical technique and patient comorbidities could potentially reduce unnecessary testing and associated health care costs. See Video Abstract. RE-TIPIFICACIÓN Y EVALUACIÓN PREOPERATORIAS: CÓMO IDENTIFICAR CUÁNDO ES NECESARIA UNA CIRUGÍA COLORRECTAL ELECTIVA ANTECEDENTES: El aumento en los costos de la atención médica exigen la reevaluación de las practicas preoperatorias de rutina. A pesar de las bajas tasas de transfusión en la cirugía colorrectal electiva, muchos hospitales continúan realizando pruebas de tipo y de cribado preoperatorios de forma rutinaria. El poresente estudio evalúa las tasas de transfusiones sanguíneas perioperatorias e identifica los factores asociados con éstas transfusiones para determinar la necesidad de pruebas de tipo y de cribado preoperatorios de forma rutinaria en cirugías colorrectales abdominales electivas. OBJETIVO: Evaluar las tasas de transfusión sanguínea perioperatoria y determinar los factores preoperatorios y quirúrgicos asociados con las transfusiones, con el fin de determinar si las pruebas de tipo y de cribado preoperatorias de forma rutinaria son necesarias en cirugías colorrectales abdominales electivas, en particular en el contexto de la cirugía mínimamente invasiva. DISEÑO: Estudio de cohortes retrospectivo. ESCENARIO: Clínica Mayo, 2019-2023. PACIENTES: Pacientes adultos sometidos a cirugías colorrectales abdominales electivas. Los criterios de exclusión incluyeron operaciones de emergencia y procedimientos no abdominales. INTERVENCIONES: Ninguna. PRINCIPALES MEDIDAS DE RESULTADOS: El resultado primario fue la incidencia de transfusión de hemoderivados intraoperatoriamente y postoperatoria inmediata (≤72 horas). Los resultados secundarios evaluaron la asociación entre las tasas de transfusión, el abordaje quirúrgico y las variables preoperatorias. RESULTADOS: De 4652 pacientes, 2770 se sometieron a cirugía mínimamente invasiva y 1882 a laparotomía. Las tasas de transfusión eritrocitaria perioperatoria fueron menores en los procedimientos mínimamente invasivos (3,0 % colectomía, 4,5 % proctectomía) que en los procedimientos abiertos (8,7 % colectomía, 21,5 % proctectomía). La proctectomía abierta fue el predictor más sólido de transfusión (OR: 12,05; IC del 95 %: 8,94-16,26; p < 0,0001), seguida de la colectomía abierta (OR: 2,59; IC del 95 %: 2,04-3,30; p < 0,0001). Los factores preoperatorios, incluyendo la clase ASA IV (OR 5,21; IC del 95 %: 1,09-24,82; p < 0,0382) y la anemia (OR 4,14; IC del 95 %: 3,09-5,55; p < 0,0001), también se asociaron significativamente con la transfusión de glóbulos rojos. LIMITACIONES: La naturaleza retrospectiva del estudio puede introducir sesgo de selección. Además, los patrones de práctica institucional pueden limitar la generalización de los hallazgos. CONCLUSIONES: Los pacientes sometidos a cirugía colorrectal mínimamente invasiva electiva tienen tasas muy bajas de transfusiones sanguíneas perioperatorias, por lo que las pruebas de detección y tipo de sangre preoperatorias de rutina probablemente sean innecesarias para esta cohorte de pacientes. Sin embargo, los pacientes sometidos a cirugías abiertas planificadas, probablemente debido a la complejidad del procedimiento, y aquellos con clase ASA IV, anemia preoperatoria o cáncer anal, tienen mayor riesgo de transfusión y podrían beneficiarse de pruebas selectivas. La implementación de un enfoque estratificado por riesgo basado en la técnica quirúrgica y las comorbilidades del paciente puede reducir las pruebas innecesarias y los costos de atención médica asociados. (Traducción—Dr. Xavier Delgadillo)
Standardizing the Definition of Each Colon Cancer Segment: Delphi Consensus on Clinical Decision-Making for Oncologic Outcomes
Kuzu, Mehmet Ayhan , Parvaiz, Amjad , Görgün, Emre , Wexner, Steven D. , Dozois, Eric J. , Hohenberger, Werner , Mišković, Danilo , Sugihara, Kenichi , Spinelli, Antonino , Wiggers, Theo , Basany, Eloy Espin, Uriburu, Juan C Patrón , Perez, Rodrigo Oliva , Lynch, Craig, Liu, Zheng , Chowdri, Nisar Ahmad , Madoff, Robert D. , West, Nick P, Şahin, Turgut , Bordeianou, Liliana , Group, On behalf of the Colon Cancer Delphi Consensus Study, Koh, Cherry , Perry, William , Park, Ji Won , Spinelli, Antonino , Wexner, Steven D , Perry, William R , Gaertner, Wolfgang B. , Benlice, Çiğdem , Bertelsen, Claus Anders , Lee, Woo-Yong , Möslein, Gabriela , Владимирович, Царьков Петр , Basany, Eloy Espin, Hahnloser, Dieter , Nilsson, Per Johan , Brown, Gina , Rouanet, Philippe , West, Nick P, Elhan, Atilla Halil , Group, On behalf of the Colon Cancer Delphi Consensus Study

Diseases of the Colon & Rectum | April 11, 2025 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1097/dcr.0000000000003739 Get It

BACKGROUND: Data registries lack a definitive classification system that distinguishes different locations of colon cancer from one another. OBJECTIVE: To establish an international consensus on the definition of primary colon cancer segment locations. DESIGN: Between December 2022 and June 2023, Delphi survey study was conducted to seek opinions from relevant international experts and eventually develop a consensus definition of each colon cancer segment. SETTING: Three-round online-based Delphi survey study. INTERVENTIONS: Online survey included 17 questions. In the first two rounds, participating experts were asked to rank each statement on a scale of 1–9 (9 is the most relevant). Consensus statements and definitions were revised according to results, obtaining a consensus score of 7–9. During the third round and online meeting, definitions and statements reached a moderate or high consensus(above 4 in more than 70% of participants) were included. MAIN OUTCOME AND MEASURE: Primary goal of our project was focused on precisely localizing the specific segment affected by primary colon cancer, rather than to identify surgical treatment or type of resection needed for particular segment. RESULTS: The first round included 331 experts, 301 (91%) completed the second round, and 295 (98%) completed the final round. Experts strongly supported the use of a “10 cm rule” to describe colon cancer sites at the flexures and anatomical landmarks for other segments. Regarding the definition of rectosigmoid cancer, experts from America and Europe reached a high consensus that the term rectosigmoid as a colon cancer location must be abolished in contrast to experts from Asia. Description of cancers overlapping segments achieved a consensus of 64%. LIMITATIONS: Subjective decisions are based on individual expert clinical experience. CONCLUSIONS: This Delphi survey, the first internationally conducted consensus study, achieved a remarkable level of consensus among a panel of global experts. Ambiguity still exists regarding overlapping lesions. See Video Abstract .
Does timing of ileostomy closure impact postoperative morbidity?
Mirande, Maxwell D. , Bews, Katherine A. , Brady, Justin T. , Shawki, Sherief , Perry, William , Mathis, Kellie L. , Perry, William R , Colibaseanu, Dorin , Behm, Kevin T. , McKenna, Nicholas P.

Colorectal Disease | April 8, 2025 | Volume: 27 | Issue: 4 | Pages: No page available

10.1111/codi.70088 Get It

Abstract Aim Reversal of diverting loop ileostomy (DLI) traditionally occurs at ≥12 weeks after formation. Early closure has been performed in attempts to reduce DLI‐associated morbidity. Therefore, the aim of this study was to determine whether time to stoma reversal impacts postoperative morbidity. Method A retrospective review was conducted using institutional‐level American College of Surgeons National Surgical Quality Improvement Program data for adult patients who underwent DLI closure between January 2012 and December 2021 across a multistate health system. Time to DLI closure was stratified into three groups: ≤12, 12–24 or 24–36 weeks. Additional data were obtained from the electronic medical record. The primary outcome was major morbidity after DLI closure. Results A total of 482 patients underwent DLI closure. Eighty four patients underwent closure at ≤12 weeks (17.4%), 300 at 12–24 weeks (62.2%) and 98 at 24–36 weeks (20.3%). The most common diagnosis at DLI formation was cancer ( n = 211, 43.8%). Patients in the ≤12 weeks closure group more commonly had ulcerative colitis or diverticular disease and a lower American Society of Anesthesiologists class than patients with closure at 24–36 weeks ( p < 0.05). There were no significant differences in complication severity, overall major morbidity or its individual components amongst the time to DLI closure groups. There were no differences in anastomotic leaks or need for laparotomy. On multivariable analysis, immunosuppressive therapy and preoperative haematocrit <30% were significant risk factors for major morbidity after DLI closure. Conclusion Major morbidity did not differ by time to DLI closure group, indicating that closure at ≤12 weeks is safe in selected patients.
Pathological staging predicts survival more accurately than clinical staging in locally advanced rectal cancer following total neoadjuvant therapy
Ng, Jyi Cheng , Sassun, Richard , Sileo, Annaclara , Perry, William , Mathis, Kellie L. , Larson, David W. , Larson, David W , Cheng, Jyi Ng , Perry, William R , Sassun, Richard

British Journal of Surgery | March 11, 2025 | Volume: 112 | Issue: 3 | Pages: No page available

10.1093/bjs/znaf034 Get It

Ventral Rectopexy: An International Expert Panel Consensus and Review of Contemporary Literature
Perry, William , Collinson, Rowan , Cornish, Julie , D’Hoore, André , Gurland, Brooke , Mellgren, Anders, Ris, Frédéric , Bordeianou, Liliana , Group, On behalf of the Ventral Rectopexy Working, Perry, William , Perry, William R , Cornish, Julie A , Ris, Frederic , Christensen, Peter , Ratto, Carlo , Stevenson, Andrew R. L. , Group, On behalf of the Ventral Rectopexy Working

Diseases of the Colon & Rectum | January 30, 2025 | Volume: 68 | Issue: 5 | Pages: 593-607

10.1097/dcr.0000000000003656 Get It

BACKGROUND: Ventral rectopexy has become increasingly used in the surgical management of rectal prolapse. There is a need for a contemporary evaluation of the role of the procedure and a description of its use in clinical practice. OBJECTIVE: To create an international consensus on ventral rectopexy. DESIGN: An expert panel undertook a scoping review of the literature to identify subject domains of interest. Literature reviews were completed for each domain with subsequent development of evidence-based and practice-based statements. These statements were compiled and reviewed by the group over a total of 9 meetings. Once statements were confirmed, supportive text was finalized, and an anonymous vote was completed using Research Electronic Data Capture to record consensus. SETTING: An international expert panel comprising colorectal surgeons who perform ventral rectopexy in a high-volume center. MAIN OUTCOME MEASURES: Statements and associated expert consensus. RESULTS: Eleven experts identified 10 domains for review: indications, contraindications, assessment and planning, consent, operative details, prostheses, complications, follow-up, recurrence and reoperative surgery, and specific considerations. After round table review, there were 17 resultant statements for consideration. Experts agreed unanimously with 13 of the statements and their accompanying text, with different experts disagreeing regarding the remaining 4 statements (91% consensus each). LIMITATIONS: Paucity of high-quality data. CONCLUSIONS: This international group developed 17 statements with high consensus. These statements provide an up-to-date summary of the literature, identify key areas for research development, and provide a reference point for colon and rectal surgeons who undertake ventral rectopexy as part of their practice. See Video Abstract . RECTOPEXIA VENTRAL: CONSENSO DE UN PANEL INTERNACIONAL DE EXPERTOS Y REVISIÓN DE LA LITERATURA CONTEMPORÁNEA ANTECEDENTES: La rectopexia ventral se ha utilizado cada vez más en el tratamiento quirúrgico del prolapso rectal. Es necesario realizar una evaluación contemporánea del rol del procedimiento y una descripción de su uso en la práctica clínica. OBJETIVO: Crear un consenso internacional sobre la rectopexia ventral. DISEÑO: Un panel de expertos realizó una revisión exhaustiva de la literatura para identificar los dominios temáticos de interés. Se completaron revisiones de la literatura para cada dominio con el desarrollo de declaraciones basadas en la evidencia y la práctica. Estas fueron compiladas y revisadas por el grupo a lo largo de un total de nueve reuniones. Una vez que se confirmaron las declaraciones, se finalizó el texto de apoyo y se completó una votación anónima utilizando REDCap para registrar el consenso. ESCENARIO: Un panel internacional de expertos compuesto por cirujanos colorrectales que realizan rectopexia ventral en un centro de alto volumen. PRINCIPALES MEDIDAS DE RESULTADOS: Declaraciones y consenso de expertos asociado. RESULTADOS: Once expertos identificaron diez dominios a revisar: indicaciones, contraindicaciones, evaluación y planificación, consentimiento, detalles operatorios, prótesis, complicaciones, seguimiento, recurrencia y cirugía reoperatoria y consideraciones específicas. Después de la revisión en mesa redonda, hubo 17 declaraciones resultantes para su consideración. Los expertos estuvieron de acuerdo unánimemente con trece de las declaraciones y su texto acompañante, y diferentes expertos estuvieron en desacuerdo con cuatro declaraciones (91% de consenso cada una). LIMITACIONES: Escasez de datos de alta calidad. CONCLUSIÓN: Este grupo internacional desarrolló 17 declaraciones con alto consenso. Estas declaraciones proporcionan un resumen actualizado de la literatura, identifican áreas claves para el desarrollo de la investigación y un punto de referencia para los cirujanos de colon y recto que realizan rectopexia ventral como parte de su práctica. (Traducción—Dr. Aurian Garcia Gonzalez )