Back to Authors

Allison, Thomas G

0000-0003-3822-888X

Mayo Clinic

Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA.

Citations 2

Bezold–Jarisch reflex mediated syncope in pulmonary arterial hypertension: An illustrative case series
Agboola, Kolade M. , Kowlgi, Gurukripa N. , DuBrock, Hilary M. , Allison, Thomas G. , DuBrock, Hilary M , Allison, Thomas G , Kowlgi, Narayan G , Csécs, Ibolya , Cajigas, Héctor

Pulmonary Circulation | October 11, 2022 | Volume: 12 | Issue: 4 | Pages: No page available

10.1002/pul2.12147 Get It

AbstractWe present a novel description of Bezold–Jarisch Reflex (BJR) during cardiopulmonary exercise testing (CPET) in three young female patients with Group 1 pulmonary arterial hypertension (PAH). These three cases presented within 26 months, representing only 0.8% of 11,387 tests on patients with PAH undergoing CPET during this time frame.
Peak Systolic Blood Pressure During the Exercise Test: Reference Values by Sex and Age and Association With Mortality
Assaf, Yazan , Barout, Ahmad, Al-Mouakeh, Ahmad , Barillas-Lara, Maria Irene , Fortin-Gamero, Sonia, Bonikowske, Amanda R. , Pepine, Carl J. , Allison, Thomas G. , Allison, Thomas G , Alhamid, Ahmad Abdul Hakim

Hypertension | April 19, 2021 | Volume: 77 | Issue: 6 | Pages: 1906-1914

10.1161/hypertensionaha.120.16570 Get It

We sought to update norms for peak systolic blood pressure (SBP) on the graded exercise test and examine its prognostic value in patients without baseline cardiovascular disease. Mayo graded exercise test data (1993–2010) were reviewed for nonimaging tests using Bruce protocol, selecting Minnesota residents 30 to 79 years without baseline cardiovascular disease. We formed a pure cohort of patients without factors significantly affecting peak SBP to determine peak SBP percentile norms by age and sex. Then we divided the full cohort of patients into 5 groups based on peak SBP percentiles: low (<10th), borderline low (10th–25th), referent (25th–75th), borderline high (75th–90th), and high (>90th). The relationship between peak SBP and mortality was tested using Cox regression adjusting for age, sex, and comorbidities affecting peak SBP or mortality. We identified 20 760 eligible patients with 7313 females (35%) and mean age 51.5±10.7 years. Our pure cohort included 7810 patients. Over 12.5±5.0 years follow-up, there were 1582 deaths, including 541 cardiovascular deaths. In the fully adjusted model, low-peak SBP was associated with increased total mortality (heart rate, 1.41 [1.19–1.66], P <0.0001) and cardiovascular mortality (heart rate, 1.54 [1.16–2.03], P =0.001), while borderline low-peak SBP was associated with increased cardiovascular mortality only (heart rate, 1.36 [1.02–1.81], P =0.027). High peak SBP was associated with increased total mortality only in the age-sex adjusted model (heart rate, 1.18 [1.02–1.36], P =0.026), not after full adjustment. We conclude that low exercise peak SBP is an independent predictor of higher total and cardiovascular mortality.