Adsit, Robert T
Mayo Clinic
Center for Tobacco Research and Intervention, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Citations 1
Relations of Current and Past Cancer with Severe Outcomes among 104,590 Hospitalized COVID-19 Patients: The COVID EHR Cohort at the University of Wisconsin
Piasecki, Thomas M. , Smith, Stevens S. , Baker, Timothy B. , Fiore, Michael C. , Adsit, Robert T. , Bolt, Daniel M. , Conner, Karen L. , Bernstein, Steven L. , Eng, Oliver S. , Lazuk, David , Gonzalez, Alec , Hayes-Birchler, Todd , Jorenby, Douglas E. , D’Angelo, Heather , Kirsch, Julie A. , Williams, Brian , Kent, Sean , Kim, Hanna , Lubanski, Stanley A. , Cai, Yuxin , Kashyap, Nitu , Mathew, Jomol , McMahan, Gabriel , Rolland, Betsy , Tindle, Hilary A. , Warren, Graham , Abu-el-rub, Noor , An, Lawrence C. , Boyd, Andrew D. , Brunzell, Darlene H., Carrillo, Victor A. , Chen, Li‐Shiun , Davis, James M. , Deshmukh, Vikrant , Dilip, Deepika , Ha, Patrick K. , Jose, Thulasee , Klass, Elizabeth , Lui, Michelle , Poon, Chester , Tong, Elisa K. , Wilson, Karen M. , Theobald, Wendy E. , Nolan, Margaret B , Piasecki, Thomas M , Smith, Stevens S , Baker, Timothy B , Fiore, Michael C , Adsit, Robert T , Bolt, Daniel M , Conner, Karen L , Bernstein, Steven L , Eng, Oliver , Lazuk, David , Gonzalez, Alec , Hayes-Birchler, Todd , Jorenby, Douglas E , D'Angelo, Heather , Kirsch, Julie A , Williams, Brian S , Kent, Sean , Kim, Hanna , Lubanski, Stanley A , Yu, Menggang , Suk, Youmi , Cai, Yuxin , Kashyap, Nitu , Mathew, Jomol , McMahan, Gabriel , Rolland, Betsy , Tindle, Hilary A , Warren, Graham W , Abu-El-Rub, Noor , An, Lawrence C , Boyd, Andrew D , Carrillo, Victor A , Chen, Li-Shiun , Davis, James M , Deshmukh, Vikrant G , Dilip, Deepika , Goldstein, Adam O , Ha, Patrick K , Iturrate, Eduardo , Jose, Thulasee , Khanna, Niharika , King, Andrea , Klass, Elizabeth , Lui, Michelle , Mermelstein, Robin J , Poon, Chester , Tong, Elisa , Wilson, Karen M , Theobald, Wendy E , Slutske, Wendy S , Nolan, Margaret , Yu, Menggang
Cancer Epidemiology, Biomarkers & Prevention | August 15, 2022 | Volume: 32 | Issue: 1 | Pages: 12-21
Abstract Background: There is mixed evidence about the relations of current versus past cancer with severe COVID-19 outcomes and how they vary by patient and cancer characteristics. Methods: Electronic health record data of 104,590 adult hospitalized patients with COVID-19 were obtained from 21 United States health systems from February 2020 through September 2021. In-hospital mortality and ICU admission were predicted from current and past cancer diagnoses. Moderation by patient characteristics, vaccination status, cancer type, and year of the pandemic was examined. Results: 6.8% of the patients had current (n = 7,141) and 6.5% had past (n = 6,749) cancer diagnoses. Current cancer predicted both severe outcomes but past cancer did not; adjusted odds ratios (aOR) for mortality were 1.58 [95% confidence interval (CI), 1.46–1.70] and 1.04 (95% CI, 0.96–1.13), respectively. Mortality rates decreased over the pandemic but the incremental risk of current cancer persisted, with the increment being larger among younger vs. older patients. Prior COVID-19 vaccination reduced mortality generally and among those with current cancer (aOR, 0.69; 95% CI, 0.53–0.90). Conclusions: Current cancer, especially among younger patients, posed a substantially increased risk for death and ICU admission among patients with COVID-19; prior COVID-19 vaccination mitigated the risk associated with current cancer. Past history of cancer was not associated with higher risks for severe COVID-19 outcomes for most cancer types. Impact: This study clarifies the characteristics that modify the risk associated with cancer on severe COVID-19 outcomes across the first 20 months of the COVID-19 pandemic. See related commentary by Egan et al., p. 3