Coppola, Giovanni
Mayo Clinic
Departments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Citations 1
AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
Sayed, Faten A. , Kodama, Lay , Fan, Li , Carling, Gillian , Udeochu, Joe C. , Le, David , Li, Qingyun , Zhou, Lu , Wong, Man Ying , Horowitz, Rose , Ye, Pearly, Mathys, Hansruedi , Wang, Minghui , Niu, Xiang , Mažutis, Linas , Jiang, Xueqiao , Gao, Fuying , Brendel, Matthew , Telpoukhovskaia, Maria A. , Tracy, Tara E. , Frost, Georgia , Zhou, Yungui, Qiu, Yue , Cheng, Zuolin , Hardy, John , Coppola, Giovanni , DeTure, Michael , Zhang, Bin , Trajnowski, John Q., Gong, Shiaoching , Luo, Wenjie , Carling, Gillian K , Wang, Xueting , Brendel, Matthew , Telpoukhovskaia, Maria , Tracy, Tara E , Frost, Georgia , Qiu, Yue , Cheng, Zuolin , Yu, Guoqiang , Hardy, John , Coppola, Giovanni , Wang, Fei , DeTure, Michael , Zhang, Bin , Xie, Lei , Trojanowski, John Q , Lee, Virginia M.‐Y. , Sinha, Subhash C , Dickson, Dennis W , Gan, Li , Mathys, Hansruedi , Li, Yaqiao , Dickson, Dennis W.
Science Translational Medicine | December 1, 2021 | Volume: 13 | Issue: 622 | Pages: No page available
R47H- TREM2 mutation enhances AKT signaling in human AD microglia and mediates proinflammatory and synaptic toxicity in a tauopathy mouse model.