Citations 1
AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
Sayed, Faten A. , Kodama, Lay , Fan, Li , Carling, Gillian , Udeochu, Joe C. , Le, David , Li, Qingyun , Zhou, Lu , Wong, Man Ying , Horowitz, Rose , Ye, Pearly, Mathys, Hansruedi , Wang, Minghui , Niu, Xiang , Mažutis, Linas , Jiang, Xueqiao , Gao, Fuying , Brendel, Matthew , Telpoukhovskaia, Maria A. , Tracy, Tara E. , Frost, Georgia , Zhou, Yungui, Qiu, Yue , Cheng, Zuolin , Hardy, John , Coppola, Giovanni , DeTure, Michael , Zhang, Bin , Trajnowski, John Q., Gong, Shiaoching , Luo, Wenjie , Carling, Gillian K , Wang, Xueting , Brendel, Matthew , Telpoukhovskaia, Maria , Tracy, Tara E , Frost, Georgia , Qiu, Yue , Cheng, Zuolin , Yu, Guoqiang , Hardy, John , Coppola, Giovanni , Wang, Fei , DeTure, Michael , Zhang, Bin , Xie, Lei , Trojanowski, John Q , Lee, Virginia M.‐Y. , Sinha, Subhash C , Dickson, Dennis W , Gan, Li , Mathys, Hansruedi , Li, Yaqiao , Dickson, Dennis W.
Science Translational Medicine | December 1, 2021 | Volume: 13 | Issue: 622 | Pages: No page available
R47H- TREM2 mutation enhances AKT signaling in human AD microglia and mediates proinflammatory and synaptic toxicity in a tauopathy mouse model.