Rodriguez, Andrew E
Mayo Clinic
Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Citations 1
MOG-IgG myelitis coexisting with systemic lupus erythematosus in the post-partum setting
Bilodeau, Philippe‐Antoine , Kumar, Vinayak , Rodriguez, Andrew , Li, Clarence T, Sánchez-Álvarez, Catalina , Thanarajasingam, Uma , Zalewski, Nicholas L. , Bilodeau, Philippe A , Rodriguez, Andrew E, Flanagan, E P , Sanchez-Alvarez, Catalina , Kumar, Vinayak , Flanagan, Eoin P.
Multiple Sclerosis Journal | October 17, 2019 | Volume: 26 | Issue: 8 | Pages: 997-1000
Background: Longitudinally extensive transverse myelitis (LETM) accompanying systemic lupus erythematosus (SLE) is often due to coexisting aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder but has not been associated with myelin oligodendrocyte glycoprotein-IgG (MOG-IgG). Objective and methods: Case report at an academic medical center. Results: A 32-year-old woman developed severe transverse myelitis (paraplegia) shortly after SLE onset in the post-partum period. Magnetic resonance imaging (MRI) revealed an LETM, cerebrospinal fluid showed marked inflammation, and testing for infections was negative. Serum live-cell-based assay for MOG-IgG was positive but aquaporin-4-IgG was negative. Conclusion: In patients with SLE and LETM, MOG-IgG testing should be considered, in addition to AQP4-IgG.