Digmann, Benjamin J
Mayo Clinic
Division of Clinical Microbiology, Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Citations 1
Differences in Duration and Degree of Cytomegalovirus DNAemia Observed With Two Standardized Quantitative Nucleic Acid Tests and Implications for Clinical Care
Meesing, Atibordee , Germer, Jeffrey J., Yao, Joseph D. , Gartner, Michelle L, Digmann, Benjamin, Digmann, Benjamin J, Razonable, Raymund R.
The Journal of Infectious Diseases | August 30, 2019 | Volume: 221 | Issue: 2 | Pages: 251-255
AbstractCytomegalovirus (CMV) viral loads overall were 0.29 log IU/mL higher with cobas CMV for use on the cobas 6800/8800 System (cobas CMV) compared with Cobas AmpliPrep/Cobas TaqMan CMV Test (CAP/CTM CMV). Cytomegalovirus DNAemia was detected 11.5 days earlier by cobas CMV, whereas clearance was delayed by 12.8 days. Cytomegalovirus remained detectable by cobas CMV in 44.2% of patients at the time of viral clearance as determined by CAP/CTM CMV. Undetectable viral load by cobas CMV at end of treatment was associated with reduced risk for retreatment (odds ratio, 0.26; 95% confidence interval, 0.04–0.99; P = .05).The use of different quantitative cytomegalovirus nucleic acid tests may affect direct patient care as a result of significant differences in reporting the degree of CMV DNAemia and the time to first detection and clearance of CMV DNAemia.