Citations 1
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
Lagares, David , Santos, Alba , Grasberger, Paula , Liu, Fei , Probst, Clemens K. , Rahimi, Rod A. , Sakai, Norihiko , Kuehl, Tobias, Ryan, Jeremy , Bhola, Patrick , Montero, Joan , Kapoor, Mohit , Varelas, Xaralabos , Tschumperlin, Daniel J. , Letai, Anthony , Tager, Andrew M. , Grasberger, Paula E , Baron, Murray , Tschumperlin, Daniel J , Lagares, David , Varelas, Xaralabos , Ryan, Jeremy
Science Translational Medicine | December 13, 2017 | Volume: 9 | Issue: 420 | Pages: No page available
ABT-263 blocks BCL-X L to induce apoptosis in human dermal fibroblasts from patients with scleroderma and in myofibroblasts in mice, reversing dermal fibrosis.