Grasberger, Paula E
Mayo Clinic
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Citations 1
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
Lagares, David , Santos, Alba , Grasberger, Paula , Liu, Fei , Probst, Clemens K. , Rahimi, Rod A. , Sakai, Norihiko , Kuehl, Tobias, Ryan, Jeremy , Bhola, Patrick , Montero, Joan , Kapoor, Mohit , Varelas, Xaralabos , Tschumperlin, Daniel J. , Letai, Anthony , Tager, Andrew M. , Grasberger, Paula E , Baron, Murray , Tschumperlin, Daniel J , Lagares, David , Varelas, Xaralabos , Ryan, Jeremy
Science Translational Medicine | December 13, 2017 | Volume: 9 | Issue: 420 | Pages: No page available
ABT-263 blocks BCL-X L to induce apoptosis in human dermal fibroblasts from patients with scleroderma and in myofibroblasts in mice, reversing dermal fibrosis.