Citations 1
Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non‐ H odgkin lymphoma subtypes
Camp, Nicola J. , Conde, Lucía , Achenbach, Sara J., Rabe, Kari G. , Novak, Anne J. , Call, Timothy G. , Bracci, Paige M. , Sillé, Fenna C.M. , Sanchez, Sylvia , Akers, Nicholas K. , Cunningham, Julie M. , Serie, Daniel, McDonnell, Shannon K. , Leis, José F., Wang, Alice H., Weinberg, J. Brice , Glenn, Martha, Link, Brian K. , Vachon, Celine M. , Lanasa, Mark C., Skibola, Christine F., Cerhan, James R. , Slager, Susan L. , Shanafelt, Tait D. , Kay, Neil E. , Vachon, Celine M. , Chaffee, Kari G. , Cerhan, James R , Link, Brian K , McDonnell, Shannon K
British Journal of Haematology | October 1, 2012 | Volume: 159 | Issue: 5 | Pages: 572-576
Summary A recent meta‐analysis of three genome‐wide association studies of chronic lymphocytic leukaemia ( CLL ) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non‐ H odgkin lymphoma ( NHL ) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10 −3 ). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.