Citations 1
Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells
Thompson, Michael A., Hamrick, Samantha K. , Borkar, Niyati A. , Ravi, Preetham , Çiçek, Yağız Anıl , Lehot, Victor , Goswami, Ritabrita , Nagaraj, Harini , Nasim, Nourina , Rotello, Vincent M , Pabelick, Christina M , Prakash, Y S , Borkar, Niyati , Rotello, Vincent M. , Pabelick, Christina M. , Prakash, Y. S.
American Journal of Physiology-Cell Physiology | August 10, 2026 | Volume: 331 | Issue: 3 | Pages: C783-C796
siRNA delivery to target cellular processes is an appealing area in lung diseases such as asthma. To realize this potential requires efficient, targeted cytosolic delivery without cellular toxicity or siRNA degradation. We demonstrate the efficacy of PONI-Guan nanoparticles in accessing airway epithelial and smooth muscle cells with specific siRNA targeting of mRNAs of interest while maintaining barrier integrity and avoiding cellular toxicity.