Citations 1
Beyond Hyperglycemia: The Role of Sodium–Glucose Cotransporter 2 Inhibitors in Cancer Treatment-related Cardiac Dysfunction
Steinberg, Rebecca , Tuli, Ritika , Reddy, Shivani , Toro-Manotas, Rafael , Marrero, Natalie , Mysore, Manu Murali, Steinberg, Rebecca S , Balanescu, Dinu Valentin , Mysore, Manu Murali
US Cardiology Review | August 3, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
Recent data suggest that sodium–glucose cotransporter 2 inhibitors have cardioprotective benefits. This effect may extend towards cardioprotection in cancer therapy-related cardiac dysfunction, with proposed mechanisms extending beyond glycemic control to include anti-inflammatory effects, oxidative stress reduction, and metabolic reprogramming. This review synthesizes potential mechanisms, observational data, and emerging trial evidence to support sodium–glucose cotransporter 2 inhibitors as a primary prevention strategy for cancer therapy-related cardiac dysfunction, particularly in anthracycline-exposed populations.