Citations 3
Dissection of PIK3CA Aberration for Cervical Adenocarcinoma Outcomes
Doran, Graeme, Cheung, Tak-Hong, Yim, So‐Fan, Yu, Mei‐Yung, Thorner, Aaron R. , Pedamallu, Chandra Sekhar , Lau, Kei-Man, Ducar, Matthew D. , Wong, Raymond R.Y., Wang, Vivian W., Nag, Anwesha , Wollison, Bruce M. , Dalgarno, Audrey, Lee, Jacqueline Ho Sze , Yeung, Suet-Ying, Wong, Lo , Leung, Shuk-On A., Mu, Yi , Mok, Samuel C. , Crum, Christopher P. , Chiu, Rossa W. K. , Berkowitz, Ross S. , Wong, Yick‐Fu, Thorner, Aaron R , Ducar, Matthew D , Lee, Jacqueline H S , Mok, Samuel C , Chung, Tony K.H. , Yim, So Fan, Worley, Michael J. , Elias, Kevin M. , Ojesina, Akinyemi I. , Yeung, Suet Ying, Horowitz, Neil S. , Davis, Michelle , Leung, Shuk On Annie , Chan, Paul K.S. , Lawrence, Michael S.
Cancers | June 28, 2021 | Volume: 13 | Issue: 13 | Pages: 3218
Personalized treatment of genetically stratified subgroups has the potential to improve outcomes in many malignant tumors. This study distills clinically meaningful prognostic/predictive genomic marker for cervical adenocarcinoma using signature genomic aberrations and single-point nonsynonymous mutation-specific droplet digital PCR (ddPCR). Mutations in PIK3CA E542K, E545K, or H1047R were detected in 41.7% of tumors. PIK3CA mutation detected in the patient’s circulating DNA collected before treatment or during follow-up was significantly associated with decreased progression-free survival or overall survival. PIK3CA mutation in the circulating DNA during follow-up after treatment predicted recurrence with 100% sensitivity and 64.29% specificity. It is the first indication of the predictive power of PIK3CA mutations in cervical adenocarcinoma. The work contributes to the development of liquid biopsies for follow up surveillance and a possibility of tailoring management of this particular women’s cancer.
Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women
Chung, Tony K.H. , Hummelen, Paul Van , Chan, Paul K.S. , Cheung, Tak Hong , Yim, So Fan, Yu, Mei , MacConaill, Laura E. , Doran, Graeme, Pedamallu, Chandra Sekhar , Ojesina, Akinyemi I. , Wong, Raymond R.Y., Wang, Vivian W., Freeman, Samuel S. , Lau, Tat‐San , Kwong, Joseph , Chan, Loucia Kit Ying , May, Taymaa , Esselen, Katharine M. , Elias, Kevin M. , Smith, David I., Crum, Christopher P. , Meyerson, Matthew , Berkowitz, Ross S. , Wong, Yick Fu, Ducar, Matthew D. , Thorner, Aaron R. , Fromer, Menachem , Worley, Michael J. , Lawrence, Michael S. , Getz, Gad , Smith, David I., Elias, Kevin M
International Journal of Cancer | January 28, 2015 | Volume: 137 | Issue: 4 | Pages: 776-783
Abstract 5047: Dysregulated microRNAs in cervical neoplasm
Wong, Yick Fu, Cheung, Tak Hong , Man, M.K.N., Yu, Mei, Yim, So Fan, Siu, Nelson S.S., Lo, Keith W.K., Doran, Graeme, Wong, Raymond R.Y., Wang, Vivian W., Smith, David I., Smith, David I., Worley, Michael J. , Chung, Tony K.H.
Cancer Research | August 9, 2012 | Volume: 72 | Issue: 8_Supplement | Pages: 5047-5047
Abstract MicroRNAs (miRNAs) play an important role in a variety of physiological processes as well as pathophysiological processes, including cancinogenesis. This study was to identify a distinct miRNA expression signature for cervical intraepithelial neoplasia (CIN) and to reveal individual miRNAs that may be involved in the development of cervical carcinoma. Expression profiling using quantitative real-time RT-PCR of 202 miRNAs was performed on micro-dissected high-grade CIN (CIN 2/3) tissues as compared to normal cervical epithelium. The expression of 12 miRNAs including miR-518a, miR-34b, miR-34c, miR-20b, miR-338, miR-9, miR-512-5p, miR-424, miR-345, miR-10a, miR-193b and miR-203 were significantly different between high-grade CIN and normal epithelium. This miRNA signature was further validated by an independent set of high-grade CIN tissue. The same characteristic signature can also be used to distinguish cervical squamous cell carcinoma (SCC) from normal controls. Target prediction analysis revealed that these dysregulated miRNAs control the apoptosis signaling pathway and cell cycle regulation. These findings contribute to understanding of the pathogenesis of cervical carcinoma at the molecular level. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5047. doi:1538-7445.AM2012-5047