Citations 1
Dissection of PIK3CA Aberration for Cervical Adenocarcinoma Outcomes
Doran, Graeme, Cheung, Tak-Hong, Yim, So‐Fan, Yu, Mei‐Yung, Thorner, Aaron R. , Pedamallu, Chandra Sekhar , Lau, Kei-Man, Ducar, Matthew D. , Wong, Raymond R.Y., Wang, Vivian W., Nag, Anwesha , Wollison, Bruce M. , Dalgarno, Audrey, Lee, Jacqueline Ho Sze , Yeung, Suet-Ying, Wong, Lo , Leung, Shuk-On A., Mu, Yi , Mok, Samuel C. , Crum, Christopher P. , Chiu, Rossa W. K. , Berkowitz, Ross S. , Wong, Yick‐Fu, Thorner, Aaron R , Ducar, Matthew D , Lee, Jacqueline H S , Mok, Samuel C , Chung, Tony K.H. , Yim, So Fan, Worley, Michael J. , Elias, Kevin M. , Ojesina, Akinyemi I. , Yeung, Suet Ying, Horowitz, Neil S. , Davis, Michelle , Leung, Shuk On Annie , Chan, Paul K.S. , Lawrence, Michael S.
Cancers | June 28, 2021 | Volume: 13 | Issue: 13 | Pages: 3218
Personalized treatment of genetically stratified subgroups has the potential to improve outcomes in many malignant tumors. This study distills clinically meaningful prognostic/predictive genomic marker for cervical adenocarcinoma using signature genomic aberrations and single-point nonsynonymous mutation-specific droplet digital PCR (ddPCR). Mutations in PIK3CA E542K, E545K, or H1047R were detected in 41.7% of tumors. PIK3CA mutation detected in the patient’s circulating DNA collected before treatment or during follow-up was significantly associated with decreased progression-free survival or overall survival. PIK3CA mutation in the circulating DNA during follow-up after treatment predicted recurrence with 100% sensitivity and 64.29% specificity. It is the first indication of the predictive power of PIK3CA mutations in cervical adenocarcinoma. The work contributes to the development of liquid biopsies for follow up surveillance and a possibility of tailoring management of this particular women’s cancer.