Citations 35
Nonlinear Z‐score modeling for improved detection of cognitive abnormality
Kornak, John , Fields, Julie A. , Kremers, Walter K. , Farmer, Sara A., Heuer, Hilary W. , Forsberg, Leah K. , Brushaber, Danielle , Rindels, Amy, Weıntraub, Sandra , Besser, Lilah M., Bordelon, Yvette , Bove, Jessica, Brannelly, Patrick , Caso, Christina, Coppola, Giovanni , Dever, Reilly, Dheel, Christina, Dickerson, Bradford, Dickinson, Susan, Domínguez, S. Carbajal, Domoto‐Reilly, Kimiko , Faber, Kelley , Ferrall, Jessica, Fishman, Ann, Gavrilova, Ralitza H. , Gearhart, Deb, Ghazanfari, Behnaz, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Grant, Ian , Haley, Dana , Hsiao, John , Hsiung, Ging‐Yuek Robin , Huey, Edward D. , Irwin, David J. , Jones, Lynne C. , Kantarci, Kejal , Karydas, Anna, Kaufer, Daniel , Kraft, Ruth, Kramer, Joel H. , Kukull, Walter A. , Ljubenkov, Peter A. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , Maldonado, Miranda, Manoochehri, Masood , McGinnis, Scott, McKinley, Emily , Mendez, Mario F. , Miller, Bruce L. , Multani, Namita, Onyike, Chiadi U. , Pantelyat, Alexander , Pearlman, Rodney , Petrucelli, Len, Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Roberson, Erik D. , Rogalski-Miller, Emily, Sengdy, Pheth, Shaw, Les, Staffaroni, Adam M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Tartaglia, Maria Carmela , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Wong, Bonnie , Boxer, Adam L. , Rosen, Howard J. , Farmer, Sara, Irwin, David J , Hsiung, Gink-Yuek , Roberson, Erik , Miller, Bruce L , Kantarci, Kejal , Pantelyat, Alex , Tartaglia, Maria Carmela , Kremers, Walter K , Domoto-Reilly, Kimiko , Dodge, Hiroko Hayama , Appleby, Brian S. , Fong, Jamie , Foroud, Tatiana , Gearhart, Deb, Goldman, Jill , Grossman, Murray , Jones, David T. , Jones, Lynne, Kerwin, Diana , Knopman, David S. , Lapid, Maria I. , Litvan, Irene , Padmanabhan, Jaya , Toga, Arthur W. , Wang, Ping , Wszołek, Zbigniew K. , Boeve, Bradley F.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | December 5, 2019 | Volume: 11 | Issue: 1 | Pages: 797-808
AbstractIntroductionConventional Z‐scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these “adjusted” Z‐scores better represent whether an individual's cognitive performance is abnormal. Extreme negative Z‐scores for individuals relative to this normative distribution are considered indicative of cognitive deficiency.MethodsIn this article, we consider nonlinear shape constrained additive models accounting for age, sex, and education (correcting for nonlinearity). Additional shape constrained additive models account for varying standard deviation of the cognitive scores with age (correcting for heterogeneity of variance).ResultsCorrected Z‐scores based on nonlinear shape constrained additive models provide improved adjustment for age, sex, and education, as indicated by higher adjusted‐R2.DiscussionNonlinearly corrected Z‐scores with respect to age, sex, and education with age‐varying residual standard deviation allow for improved detection of non‐normative extreme cognitive scores.
Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration
Olney, Nicholas , Ong, Elise, Goh, Sheng‐Yang M., Bajorek, Lynn, Dever, Reilly, Staffaroni, Adam M. , Bock, Meredith , Chiang, Kevin, Ljubenkov, Peter A. , Kornak, John , Heuer, Hilary W. , Rascovsky, Katya, Wolf, Amelia, Bove, Jessica, Bordelon, Yvette , Brannelly, Patrick , Brushaber, Danielle , Caso, Christine, Coppola, Giovanni , Dickinson, Susan, Domoto‐Reilly, Kimiko , Faber, Kelly, Ferrall, Jessica, Fields, Julie A. , Fishman, Ann, Foroud, Tatiana M., Forsberg, Leah K. , Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur , Graff‐Radford, Jonathan, Graff‐Radford, Neill R. , Grant, Ian , Haley, Dana , Hsiung, Ging‐Yuek Robin , Huey, Edward D. , Irwin, David J. , Kantarci, Kejal , Karydas, Anna M., Kaufer, Daniel , Kramer, Joel H. , Kraft, Ruth, Kremers, Walter K. , Kukull, Walter A. , Mackenzie, Ian R. , Maldonado, Miranda, Manoochehri, Masood , McGinnis, Scott M., McKinley, Emily , Mendez, Mario F. , Miller, Bruce L. , Onyike, Chiadi U. , Pantelyat, Alexander , Pearlman, Rodney , Petrucelli, Len, Potter, Madeleine, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Roberson, Erik D. , Rogalskı, Emily , Sengdy, Pheth, Shaw, Leslie M. , Syrjanen, Jeremy A. , Tartaglia, Maria Carmela , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Weıntraub, Sandra , Wong, Bonnie , Boxer, Adam L. , Rosen, Howard J. , consortia, on behalf of the ARTFL and LEFFTDS, Gearhart, Debra J, Boeve, Brad F, Irwin, David J , Hsiung, Gink-Yuek , Roberson, Erik , Miller, Bruce L , Kantarci, Kejal , Pantelyat, Alex , Tartaglia, Maria Carmela , Kremers, Walter K , Domoto-Reilly, Kimiko , Cobigo, Yann , Wang, Ping , Appleby, Brian S. , Dickerson, Bradford Clark , Fong, Jamie , Goldman, Jill , Graff‐Radford, Jonathan , Grossman, Murray , Jones, David T. , Kerwin, Diana , Knopman, David S. , Lapid, Maria I. , Litvan, Irene , Potter, Madeleine, Toga, Arthur W. , Wszołek, Zbigniew K. , Boeve, Bradley F. , consortia, on behalf of the ARTFL and LEFFTDS
Alzheimer's & Dementia | November 26, 2019 | Volume: 16 | Issue: 1 | Pages: 49-59
AbstractIntroductionThe Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects longitudinal studies were designed to describe the natural history of familial‐frontotemporal lobar degeneration due to autosomal dominant mutations.MethodsWe examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 MAPT, GRN, and C9orf72 family members, including 102 non–mutation carriers, 103 asymptomatic carriers, 43 mildly/questionably symptomatic carriers, and 72 carriers with dementia.ResultsAsymptomatic carriers showed similar scores on all clinical measures compared with noncarriers but reduced frontal and temporal volumes. Those with mild/questionable impairment showed decreased verbal recall, fluency, and Trail Making Test performance and impaired mood and self‐monitoring. Dementia was associated with impairment in all measures. All MAPT carriers with dementia showed temporal atrophy, but otherwise, there was no single cognitive test or brain region that was abnormal in all subjects.DiscussionImaging changes appear to precede clinical changes in familial‐frontotemporal lobar degeneration, but specific early clinical and imaging changes vary across individuals.
O4‐03‐01: FRONTOTEMPORAL LOBAR DEGENERATION RESEARCH IN NORTH AMERICA: PROGRESS IN THE ARTFL/LEFFTDS CONSORTIA
Heuer, Hilary W. , Boxer, Adam L. , Rosen, Howard J. , Forsberg, Leah K. , Brushaber, Danielle , Bordelon, Yvette , Coppola, Giovanni , Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff-Radford, N. R., Grant, Ian , Huey, Edward D. , Karydas, Anna M., Kaufer, Daniel , Kramer, Joel H. , Ljubenkov, Peter A. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , McGinnis, Scott M., Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Pearlman, Rodney , Petrucelli, Leonard , Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Rogalskı, Emily , Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Weıntraub, Sandra , Consortia, ARTFL and LEFFTDS, Boeve, Bradley F. , Appleby, Brian S. , Brannelly, Patrick , Domoto‐Reilly, Kimiko , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wong, Bonnie , Wszołek, Zbigniew K. , Consortia, ARTFL and LEFFTDS
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_23 | Pages: No page available
P2‐329: TRACKING WHITE MATTER DEGENERATION IN ASYMPTOMATIC AND SYMPTOMATIC MAPT MUTATION CARRIERS WITH DTI
Tosakulwong, Nirubol , Lesnick, Timothy G. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boxer, Adam L. , Rosen, Howard J. , Chen, Qin , Boeve, Bradley F. , Schwarz, Christopher G. , Reid, Robert I. , Brannelly, Patrick , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jack, Clifford R. , Jones, David T. , Jones, Lynne, Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wong, Bonnie , Wszołek, Zbigniew K. , Kantarci, Kejal
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available
P2‐314: THE MULTIDOMAIN IMPAIRMENT RATING (MIR) SCALE: INITIAL RELIABILITY DATA ON A MULTIDIMENSIONAL SCALE DESIGNED FOR FTLD SPECTRUM DISORDERS
Forsberg, Leah K. , Boxer, Adam L. , Rosen, Howard J. , Kornak, John , Heuer, Hilary W. , Fields, Julie A. , Brushaber, Danielle , Sturm, Virginia E. , Staffaroni, Adam M. , Ljubenkov, Peter A. , Denver, Reilly, Ong, Elise, Bordelon, Yvette , Coppola, Giovanni, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff-Radford, N. R., Huey, Edward D. , Karydas, Anna M., Kaufer, Daniel , Kraft, Ruth, Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , McGinnis, Scott M., Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Rogalskı, Emily , Shaw, Leslie M. , Sutherland, M. Anne, Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Machulda, Mary M. , Appleby, Brian S. , Brannelly, Patrick , Coppola, Giovanni, Domoto‐Reilly, Kimiko , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Sutherland, Marg, Tartaglia, Maria Carmela , Toga, Arthur W. , Wong, Bonnie , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available
O2‐14‐06: DIFFERENCES BETWEEN SPORADIC AND FAMILIAL BEHAVIORAL VARIANT FTD IN ADVANCING RESEARCH AND TREATMENT FOR FTLD (ARTFL) CLINICAL RESEARCH CONSORTIUM
Boxer, Adam L. , Heuer, Hilary W. , Wang, Ping , Rascovsky, Katya, Rosen, Howard J. , Coppola, Giovanni , Dickerson, Brad C., Bordelon, Yvette , Faber, Kelley, Fields, Julie A. , Ghoshal, Nupur , Graff-Radford, N. R., Huey, Edward D. , Kaufer, Daniel , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lungu, Codrin , Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Rademakers, Rosa , Sutherland, Marg, Weıntraub, Sandra , Rogalskı, Emily , Wang, Ping, Boeve, Bradley F. , Grossman, Murray , Domoto‐Reilly, Kimiko , Feldman, Howard , Fong, Jamie , Foroud, Tatiana , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_12 | Pages: No page available
O2‐14‐02: THE CLINICAL SPECTRUM OF FRONTOTEMPORAL LOBAR DEGENERATION IN NORTH AMERICA: BASELINE CHARACTERISTICS OF THE FIRST 912 PARTICIPANTS FROM THE ADVANCING RESEARCH AND TREATMENT IN FTLD (ARTFL) CLINICAL RESEARCH CONSORTIUM
Heuer, Hilary W. , Boxer, Adam L. , Rosen, Howard J. , Dickerson, Brad C., Bordelon, Yvette , Brushaber, Danielle , Faber, Kelley, Fields, Julie A. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Huey, Edward D. , Kaufer, Daniel , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lungu, Codrin , Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Sutherland, Marg, Weıntraub, Sandra , Boeve, Bradley F. , Grossman, Murray , Appleby, Brian S. , Domoto‐Reilly, Kimiko , Feldman, Howard , Fong, Jamie , Foroud, Tatiana , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_12 | Pages: No page available
O2‐14‐01: CHARACTERISTICS AND PROGRESS OF 320 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL
Forsberg, Leah K. , Rosen, Howard J. , Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott M., Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Sutherland, Marg, Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_12 | Pages: No page available
O1‐08‐01: THE NIH‐EXAMINER IS SENSITIVE TO COGNITIVE CHANGES IN ASYMPTOMATIC AND MILDLY SYMPTOMATIC FAMILIAL FRONTOTEMPORAL DEMENTIA
Staffaroni, Adam M. , Bajorek, Lynn, Ljubenkov, Peter A. , Casaletto, Kaitlin B. , Rascovsky, Katya, Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Radford, Jonathan Graff, Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Sutherland, Margaret , Syrjanen, Jeremy A. , Taylor, Joanne, Weıntraub, Sandra , Rosen, Howard J. , Kramer, Joel H. , Elahi, Fanny M. , Boeve, Bradley F. , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_4 | Pages: No page available
P1‐433: GRAY MATTER DEFICITS IN SYMPTOMATIC AND PRESYMPTOMATIC MAPT MUTATION CARRIERS
Chu, Stephanie A. , Flagan, Taru , Papma, Janne M. , Deng, Jersey, Rosen, Howard J. , Boxer, Adam L. , Heuer, Hilary W. , Brushaber, Danielle , Coppola, Giovanni , Dickerson, Brad C., Bordelon, Yvette , Dheel, Christina, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Huey, Edward D. , Kaufer, Daniel , Karydas, Anna M., Klein, Alex, Kornak, John , Kramer, Joel H. , Laxineta, Samara, Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Potter, Madeline, Rademakers, Rosa , Tatton, Nadine , Vetor, Ashley, Weıntraub, Sandra , Lee, Suzee E. , Jiskoot, Lize C. , Seeley, William W. , Boeve, Bradley F. , Grossman, Murray , Feldman, Howard , Fong, Jamie , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Klein, Alex, Knopman, David S. , Kukull, Walter A. , Lapid, Maria I. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K. , Swieten, John C. van
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_8 | Pages: No page available