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Albert, Marilyn

Mayo Clinic

Johns Hopkins University

Citations 15

Longitudinal decline in mild‐to‐moderate Alzheimer's disease: Analyses of placebo data from clinical trials
Thomas, Ronald G. , Albert, Marilyn, Petersen, Ronald C. , Aisen, Paul

Alzheimer's & Dementia | February 23, 2016 | Volume: 12 | Issue: 5 | Pages: 598-603

10.1016/j.jalz.2016.01.002 Get It

AbstractIntroductionAccurate estimates of cognitive and clinical decline rates are essential to the design of clinical trials in Alzheimer's disease (AD) dementia.MethodsTo investigate the trajectories of individuals enrolled in therapeutic trials in mild‐to‐moderate AD, we analyzed the placebo arm data from 20 clinical trials including over 4500 subjects. We analyzed decline as measured by two cognitive instruments, the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAScog) and the Mini‐Mental State Examination, and one clinical rating scale, the Clinical Dementia Rating Sum of Boxes.ResultsTrajectories were generally similar across trials and nearly linear. Greater cognitive impairment at baseline, younger age, and greater education were associated with increased rate of cognitive decline. Effect sizes for the ADAScog were generated as a function of population characteristics.DiscussionThese data will inform the design of future studies of potential disease‐modifying therapies for mild‐to‐moderate AD dementia.
Midlife Hypertension and 20-Year Cognitive Change
Schneider, Andrea L.C. , Albert, Marilyn, Alonso, Álvaro , Bandeen‐Roche, Karen , Coker, Laura H., Rawlings, Andreea M. , Sharrett, A. Richey, Wruck, Lisa , Gottesman, Rebecca F. , Coresh, Josef , Knopman, David S. , Power, Melinda C. , Mosley, Thomas H. , Alonso, Alvaro , Schneider, Andrea L C , Wruck, Lisa M

JAMA Neurology | August 4, 2014 | Volume: 71 | Issue: 10 | Pages: 1218

10.1001/jamaneurol.2014.1646 Get It

P1–334: Development and implementation of the National Alzheimer's Prevention Registry
High, Nellie, Aisen, Paul , Albert, Marilyn, Brown, Kyle, Comer, Meryl, Petersen, Ronald C. , Strobel, Gabrielle, Weiner, Michael W. , Tariot, Pierre N. , Reiman, Eric M. , Langbaum, Jessica B. S. , Cummings, Jeffrey L. , Manly, Jennifer J. , Sperling, Reisa Anne

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_7 | Pages: No page available

10.1016/j.jalz.2013.05.560 Get It

P3–295: The Placebo Data Analysis in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) Clinical Trials Project: Overview of progress in trial data collection, and key findings from the pooled Alzheimer's disease trial datasets
Thomas, Ronald J. , Petersen, Ronald, Carrillo, Maria, Albert, Marilyn, Aisen, Paul, Initiative, Alzheimer's Disease Neuroimaging, Siuciak, Judith A. , Initiative, Alzheimer's Disease Neuroimaging

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_16 | Pages: No page available

10.1016/j.jalz.2013.05.1369 Get It

P3‐384: The placebo data analysis in Alzheimer's disease and mild cognitive impairment (MCI) clinical trials project: Overview of progress in trial data collection, and key findings from the pooled MCI trial datasets
Aisen, Paul, Thomas, Ronald G. , Mohs, Richard C. , Petersen, Ronald C. , Albert, Marilyn, Initiative, The Alzheimer's Disease Neuroimaging, Carrillo, María C. , Siuciak, Judith A. , Initiative, The Alzheimer's Disease Neuroimaging

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_16 | Pages: No page available

10.1016/j.jalz.2012.05.1609 Get It