Citations 1
Anti-fibrinolytic strategies improve liver regeneration in mice and reduce post-hepatectomy liver failure in patients
Li, Zhihao , Wei, Zimu , Groeneveld, Dafna J. , Strilchuk, Amy W. , Flick, Matthew J., Dong, Yawen , Podrascanin, V. , Truty, Mark, Kendrick, Michael L., Cleary, S., Warner, Susanne G., Assinger, Alice, Kastrup, Christian J. , Karanicolas, Paul, Starlinger, P, Smoot, Rory L , Kastrup, Christian J , Luyendyk, James P , Li, Zhihao , Dong, Yawen , Flick, Matthew J. , Truty, Mark J. , Kendrick, Michael L. , Cleary, Sean P. , Warner, Susanne G. , Smoot, Rory L. , Assinger, Alice , Karanicolas, Paul J. , Luyendyk, James P.
Blood Journal | June 11, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
Pharmacological plasminogen reduction enhanced liver regeneration experimentally and clinically. siRNA-induced plasminogen deficiency promoted hepatocyte proliferation after partial hepatectomy in mice, contrasting genetic deficiency models. In the HeLiX trial, tranexamic acid reduced post-hepatectomy liver failure odds, suggesting a novel therapeutic strategy.