Citations 1
Differential effects of α7nAChR activation in a murine model of asthma
Borkar, Niyati A. , Lee, Kenge K., Thompson, Michael A, Bartman, Colleen M. , Nesbitt, Lisa, Hamrick, Samantha K. , Fang, Yun Hua, Prakash, Y. S. , Pabelick, Christina M, Pabelick, Christina M. , Nesbitt, Lisa L, Prakash, Y S , Pabelick, Christina M , Bartman, Colleen M , Thompson, Michael A.
American Journal of Physiology-Lung Cellular and Molecular Physiology | March 30, 2026 | Volume: 330 | Issue: 5 | Pages: L539-L556
The studies demonstrate the differential effects of the nicotinic acetylcholine receptors (nAChRs) regulating airway hyperreactivity (AHR) and remodeling in a mixed allergen model of asthma. We compared wild-type (WT) versus global α7nAChR knockout (Glα7KO) versus smooth muscle-specific α7nAChR KO (smα7KO) mice. We found that smα7KO improved lung function and AHR in mice challenged with MA and in the presence of nicotine, whereas MA-challenged Glα7KO in the presence of nicotine showed worsened AHR.