Citations 1
A long-term human adipocyte organoid model reveals aging-associated responses to intermittent hypoxia
Dong, Yunzhou , Wang, Jingjing , Feng, Feifei, Ali, Isra H. , Chen, Lida, Karim, Shahid , Bock, Joshua M. , Somers, Virend K., Somers, Virend K. , Somers, Virend K. , Bock, Joshua
American Journal of Physiology-Cell Physiology | March 18, 2026 | Volume: 330 | Issue: 4 | Pages: C1093-C1106
Establishes a robust long-term human adipocyte organoid culture system maintained for over 90 days. Recapitulates key features of OSA-related intermittent hypoxia in human adipocytes in vitro. Demonstrates IH-induced adipocyte aging, including ultrastructural damage and epigenetic reprogramming. Identifies impaired adipogenesis and insulin signaling under intermittent hypoxia. Provides a physiologically relevant platform for mechanistic studies and drug screening.