Citations 1
Integrated glucagon model for estimation of α-cell responsivity to glucose and amino acids during graded glucose infusion
Boscolo, Federica, Mohan, Sneha , LAURENTI, MARCELLO C. , Kohlenberg, Jacob , Christie, Hannah E. , Vella, Adrian, Man, Chiara Dalla, Man, Chiara Dalla , Vella, Adrian , Mohan, Sneha , Boscolo, Francesca S. , Boscolo, Federica , Egan, Aoife M. , Vella, Adrian , Dalla Man, Chiara , Christie, Hannah E
American Journal of Physiology-Endocrinology and Metabolism | March 12, 2026 | Volume: 330 | Issue: 4 | Pages: E530-E539
In this study, we propose two new mathematical models able to quantify glucagon secretion during a graded glucose infusion, in the presence and absence of amino acids. The models provide an index of α-cell responsivity, G 50 , i.e., the glucose increase required to suppress glucose secretion rate (GSR) by 50%. Results show that the presence of amino acids reduced α-cell responsivity to glucose.