Citations 1
Prognostic Significance of Prolonged QTc Interval in Patients on Dialysis: A Retrospective Cohort Study
Pham, Hoang Nhat, Ibrahim, R, Giauque, Nathan A., Mahmoud, Ahmed K., Dreher, Luke, Scott, Luis R., Ayoub, Chadi, Arsanjani, Reza, LeMond, Lisa , Singh, Amitoj, Sorajja, Dan , Ayoub, Chadi , Ayoub, Chadi , Pham, Hoang Nhat , Giauque, Nathan Anthony, Mahmoud, Ahmed K , Dreher, Luke , Scott, Luis R. , Arsanjani, Reza , Singh, Amitoj
Journal of Arrhythmia | February 19, 2026 | Volume: 42 | Issue: 1 | Pages: No page available
ABSTRACT Background Prolonged QT interval is common in end‐stage renal disease (ESRD) on dialysis, but its long‐term cardiovascular (CV) implications remain unclear. Methods Using TriNetX network (2010–2024), we identified adults with ESRD on dialysis and categorized them by QTc status. After 1:1 propensity score matching ( n = 3428/group), outcomes (hazard ratio [HR]) were assessed using Cox regression. Results Prolonged QTc (> 500 ms) was associated with higher risk of all‐cause mortality (HR 1.67; p < 0.001), MACEs (HR 1.40; p < 0.001), cardiac arrest (HR 1.75; p < 0.001), sustained ventricular arrhythmia (HR 1.66; p < 0.001), new‐onset atrial fibrillation (HR 1.12; p = 0.01), and acute myocardial infarction (HR 2.19; p < 0.001). Conclusions In ESRD patients on dialysis, prolonged QT interval was independently associated with adverse CV outcomes and mortality.