Citations 1
Percutaneous Left Atrial Appendage Occlusion for Atrial Fibrillation in Cardiac Amyloidosis
Almakadma, Abdul Hakim , Ibrahim, Ramzi, Pham, Hoang Nhat, Habib, Eiad, Mahmoud, Ahmed K., Awad, Kamal, Bhakta, Mayurkumar D. , Yang, Eric H., Masry, Hicham Z. El, Ayoub, Chadi, Arsanjani, Reza, Ayoub, Chadi , Masry, Hicham El , Awad, Kamal , El Masry, Hicham , Ayoub, Chadi , Ibrahim, Ramzi , Pham, Hoang Nhat , Habib, Eiad , Mahmoud, Ahmed K , Awad, Kamal , Yang, Eric H. , Arsanjani, Reza
Journal of Arrhythmia | January 27, 2026 | Volume: 42 | Issue: 1 | Pages: No page available
ABSTRACT Background Cardiac amyloidosis (CA) is frequently complicated by atrial fibrillation (AF), yet outcomes after left atrial appendage occlusion (LAAO) in this population remain poorly defined. Methods We conducted a retrospective TriNetX study of adults with AF undergoing LAAO, comparing patients with and without CA after 1:1 propensity matching. Outcomes were assessed using Kaplan–Meier analyses and Cox regression. Results Among 532 matched pairs, mortality and major adverse cardiovascular events were similar between groups, whereas major bleeding was higher in CA (HR 1.90). Conclusions LAAO yields comparable ischemic outcomes in CA, though bleeding risk is increased.