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Mielke, Michelle M.

https://orcid.org/0000-0001-7177-1185

Mayo Clinic

Wake Forest University Health Sciences

Citations 530

P1‐131: Excessive daytime sleepiness is comparable in behavioral variant frontotemporal dementia and Alzheimer's disease dementia but greater in dementia with lewy bodies
Boeve, Angelica, Aakre, Jeremiah A. , Silber, Michael H. , Fields, Julie A. , Graff-Radford, N. R., Radford, Jonathan Graff, Petersen, Ronald C. , Ferman, Tanis J. , Louis, Erik K. St. , Machulda, Mary M. , Mielke, Michelle M. , Geda, Yonas E. , Jones, David T. , Knopman, David S. , Boeve, Bradley F.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_8 | Pages: No page available

10.1016/j.jalz.2015.06.329 Get It

O3‐01‐02: Treatment with 17β‐estradiol in postmenopausal women is associated with lower PiB‐PET retention
Lowe, Val J. , Tosakulwong, Nirubol , Lesnick, Timothy G. , Gunter, Jeffrey L. , Shuster, Lynne T., Bailey, Kent R. , Rocca, Walter A. , Miller, Virginia M. , Senjem, Matthew L. , Mielke, Michelle M. , Jack, Clifford R. , Kantarci, Kejal

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_5 | Pages: No page available

10.1016/j.jalz.2015.07.237 Get It

IC‐P‐151: Longitudinal outcomes and profiles of distinct biomarker clusters based on vascular disease, neurodegeneration, and amyloid deposition
Przybelski, Scott A. , Lesnick, Timothy G. , Roberts, Rosebud O., Lowe, Val J. , Rocca, Walter A. , Petersen, Ronald C. , Vemuri, Prashanthi , Knopman, David S. , Machulda, Mary M. , Mielke, Michelle M. , Geda, Yonas E. , Jack, Clifford R.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2015.06.174 Get It

F5‐04‐04: Scd in a population‐based sample: Progression to MCI
Petersen, Ronald C. , Swenson-Dravis, Dana M., Roberts, Rosebud O., Edwards, Kelly K., Knopman, David S. , Mielke, Michelle M.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2015.07.438 Get It

O2‐09‐03: Evidence of reduced neuronal plasticity to education in ApoE‐ɛ4 carriers
Overgaard, Shauna, Przybelski, Scott A. , Lowe, Val J. , Petersen, Ronald C. , Machulda, Mary M. , Mielke, Michelle M. , Knopman, David S. , Jack, Clifford R. , Vemuri, Prashanthi

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_4 | Pages: No page available

10.1016/j.jalz.2015.07.179 Get It

P2‐170: Plasma ceramides predict age‐related differences in white matter microstructure
Venkatraman, Vijay , An, Yang , Bandaru, Veera Venkata Ratnam, Resnick, Susan M. , Gonzalez, Christopher E. , Landman, Bennett A , Haughey, Norman J. , Ferrucci, Luigi , Mielke, Michelle M.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_12 | Pages: No page available

10.1016/j.jalz.2015.06.709 Get It

Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community
Petersen, Ronald C. , Wiste, Heather J. , Weigand, Stephen D. , Rocca, Walter A. , Roberts, Rosebud O., Lowe, Val J. , Geda, Yonas E. , Jack, Clifford R. , Mielke, Michelle M. , Knopman, David S. , Pankratz, V. Shane , Machulda, Mary M. , Jack, Clifford R , Geda, Yonas E

JAMA Neurology | November 23, 2015 | Volume: 73 | Issue: 1 | Pages: 85

10.1001/jamaneurol.2015.3098 Get It

Influence of amyloid and APOE on cognitive performance in a late middle‐aged cohort
Mielke, Michelle M. , Hagen, Clinton E., Christianson, Teresa J., Roberts, Rosebud O., Vemuri, Prashanthi , Lowe, Val J. , Kremers, Walter K. , Jack, Clifford R. , Petersen, Ronald C. , Machulda, Mary M. , Knopman, David S. , Jack, Clifford R , Mielke, Michelle M , Vemuri, Prashanthi , Kremers, Walter K

Alzheimer's & Dementia | November 19, 2015 | Volume: 12 | Issue: 3 | Pages: 281-291

10.1016/j.jalz.2015.09.010 Get It

AbstractIntroductionFew studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle‐aged individuals.MethodsWe included 464 cognitively normal, test‐naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, mean age of 62.7 (range, 51–71 years), enrolled in the Mayo Clinic Study of Aging. Participants completed multiple cognitive assessments, including a standard neuropsychological battery and the CogState computerized battery, over 30 months of follow‐up. Linear mixed models were used to examine the effects of amyloid and APOE genotype on baseline cognition and cognitive decline.ResultsElevated amyloid was not associated with tests of episodic memory but did predict declines on tests of executive function. APOE genotype was not associated with cognition. Among APOE ɛ4 noncarriers, higher amyloid was predictive of decline on tests of executive function and on one episodic memory test.DiscussionElevated amyloidosis and APOE genotype do not appear to exert a dramatic influence on cognition in middle age.
Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia
Roberts, Rosebud O., Christianson, Teresa J., Kremers, Walter K. , Mielke, Michelle M. , Vassilaki, Maria , Alhurani, Rabe E., Geda, Yonas E. , Petersen, Ronald C. , Christianson, Teresa J H, Machulda, Mary M. , Knopman, David S. , Mielke, Michelle M , Geda, Yonas E , Kremers, Walter K

JAMA Neurology | November 16, 2015 | Volume: 73 | Issue: 1 | Pages: 93

10.1001/jamaneurol.2015.2952 Get It

Atrial fibrillation, cognitive impairment, and neuroimaging
Graff‐Radford, Jonathan , Madhavan, Malini , Vemuri, Prashanthi , Cha, Ruth H., Mielke, Michelle M. , Kantarci, Kejal , Lowe, Val J. , Senjem, Matthew L. , Gunter, Jeffrey L. , Petersen, Ronald C. , Jack, Clifford R. , Roberts, Rosebud O., Rabinstein, Alejandro A. , Cha, Ruth H., Knopman, David S. , Jack, Clifford R , Mielke, Michelle M , Vemuri, Prashanthi , Senjem, Matthew L , Kantarci, Kejal

Alzheimer's & Dementia | October 25, 2015 | Volume: 12 | Issue: 4 | Pages: 391-398

10.1016/j.jalz.2015.08.164 Get It

AbstractIntroductionThe objective of our study was to investigate cross‐sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI).MethodsMagnetic resonance imaging scans of individuals from a population‐based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging.ResultsAtrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57–5.70; P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45–1.80; P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96–2.34; P = .08) for no atrial fibrillation and any infarction.DiscussionParticipants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.