Citations 1
Modeling the effect of glucagon on endogenous glucose production in healthy individuals under meal-like conditions
Faggionato, Edoardo , Tonello, Alessio, LAURENTI, MARCELLO C. , Vella, Adrian , Man, Chiara Dalla , Dalla Man, Chiara , Vella, Adrian
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | November 5, 2025 | Volume: 329 | Issue: 6 | Pages: R894-R904
The model can be used to quantify hepatic glucagon and insulin sensitivity, accounting also for glucagon evanescence over time. The ability to quantify glucagon effects on postprandial glucose metabolism will further our understanding of its role in the onset and progression of type 2 diabetes. These findings can also be used in the design of novel glucagon-based therapies where accurate modeling of glucagon action is required to meet efficacy and safety standards.