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Kittner, Steven J.

https://orcid.org/0000-0002-8457-8744

Mayo Clinic

University of Maryland, Baltimore

Citations 44

NINDS Stroke Genetics Network (SiGN) Experience with the Causative Classification System
Worrall, Bradford B. , Brown, Robert D. , Ay, Hakan , McArdle, Patrick F. , Kittner, Steven J. , Meschia, James F. , Rundek, Tatjana

International Journal of Stroke | May 21, 2013 | Volume: 8 | Issue: 4 | Pages: E9-E9

10.1111/j.1747-4949.2012.00944.x Get It

Genome-Wide Association Analysis of Ischemic Stroke in Young Adults
Cheng, Yu-Ching , O’Connell, Jeffrey R. , Dueker, Nicole , McArdle, Patrick F. , Sparks, Mary J., Shen, Jess, Laurie, Cathy C. , Doheny, Kimberly F. , Pugh, Elizabeth, Brott, Thomas G. , Brown, Robert D., Nalls, Michael A., Rich, Stephen S. , Worrall, Bradford B. , Anderson, Christopher D. , Biffi, Alessandro , Cortellini, Lynelle, Furie, Karen L., Rost, Natalia S. , Manolio, Teri A. , Kittner, Steven J. , Mitchell, Braxton D. , Cole, John W. , Stine, Oscar Colin , Nelson, Sarah C. , Ling, Hua , Meschia, James F. , Rosand, Jonathan M. , Rich, Stephen S , Mitchell, Braxton D

G3 Genes|Genomes|Genetics | December 14, 2011 | Volume: 1 | Issue: 6 | Pages: 505-514

10.1534/g3.111.001164 Get It

Abstract Ischemic stroke (IS) is among the leading causes of death in Western countries. There is a significant genetic component to IS susceptibility, especially among young adults. To date, research to identify genetic loci predisposing to stroke has met only with limited success. We performed a genome-wide association (GWA) analysis of early-onset IS to identify potential stroke susceptibility loci. The GWA analysis was conducted by genotyping 1 million SNPs in a biracial population of 889 IS cases and 927 controls, ages 15–49 years. Genotypes were imputed using the HapMap3 reference panel to provide 1.4 million SNPs for analysis. Logistic regression models adjusting for age, recruitment stages, and population structure were used to determine the association of IS with individual SNPs. Although no single SNP reached genome-wide significance (P < 5 × 10−8), we identified two SNPs in chromosome 2q23.3, rs2304556 (in FMNL2; P = 1.2 × 10−7) and rs1986743 (in ARL6IP6; P = 2.7 × 10−7), strongly associated with early-onset stroke. These data suggest that a novel locus on human chromosome 2q23.3 may be associated with IS susceptibility among young adults.