Vaqué‐Alcázar, Lídia
https://orcid.org/0000-0002-6776-6559
Mayo Clinic
Universitat Autònoma de Barcelona
Citations 2
Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome
Giménez, Sandra , Vaqué-Alcázar, Lídia, Clos, Susana, Benejam, Bessy, Carmona-Iragui, Maria, Maure‐Blesa, Lucía, Videla, Laura, Zhu, Nuole , Altuna, Miren, Arranz, Javier, Barroeta, Isabel , Rodríguez-Baz, Íñigo, Bueno, Ana, Fernandez, Susana, Pertierra, Lucía , Alcolea, Daniel, Miller, Bruce, Ruiz, Joaquin, Wu, Hau-Tieng, Lleó, Alberto, Osorio, Ricardo S, Blessing, Esther M, Fortea, Juan, Vaqué‐Alcázar, Lídia , Clos, S. , Benejam, Bessy , Carmona‐Iragui, María , Videla, Laura , Altuna, Miren , Arranz, Javier , Rodríguez‐Baz, Íñigo , Bejanin, Alexandre , Fernández, Susana , Soriano, Laura del Hoyo , Alcolea, Daniel , Miller, Bruce L , Grinberg, Lea T. , Lisgaras, Christos Panagiotis , Lleó, Alberto , Osorio, Ricardo S. , Fortea, Juan
Alzheimer's & Dementia | April 30, 2026 | Volume: 22 | Issue: 5 | Pages: No page available
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults with DS (108 asymptomatic; 32 AD dementia) and 41 unimpaired controls. General linear models, adjusted for age, sex, sleep efficiency, and obstructive sleep apnea (OSA) severity, tested group differences, with interaction terms included to evaluate group‐specific associations. RESULTS DS showed lower relative amplitude and higher nocturnal activity, already in asymptomatic individuals. Rhythm strength declined further with AD progression, while regularity and phase timing remained preserved until dementia. Findings were independent of sleep duration and OSA. DISCUSSION Adults with DS showed early RAR disturbance that progressed across the AD continuum, paralleling sporadic AD. Circadian RAR features may be scalable biomarkers of AD progression.
Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia
Castro, J. García , Rubio‐Guerra, Sara , Casaletto, Kaitlin B. , Selma, Judit , Memel, Molly , Vaqué‐Alcázar, Lídia , Morcillo‐Nieto, Alejandra O. , Arriola‐Infante, José Enrique , Dols‐Icardo, Oriol , Bejanin, Alexandre , Belbin, Olivia , Carmona‐Iragui, María , Barroeta, Isabel , Santos‐Santos, Miguel , Saudinós, María Belen Sánchez, Sala, Isabel , Heuer, Hilary W. , Forsberg, Leah K. , Kantarci, Kejal, Staffaroni, Adam M. , Rankin, Katherine P. , Boxer, Adam L. , Rosen, Howard J. , Lleó, Alberto, Illán‐Gala, Ignacio , Kantarci, Kejal , Belbin, Olivia , Garcia Castro, Jesús , Illán-Gala, Ignacio , Bejanin, Alexandre , Kantarci, Kejal , Selma‐González, Judit , Fortea, Juan , Alcolea, Daniel , Sánchez‐Saudinós, María Belén , Tartaglia, Maria Carmela , Boeve, Bradley F. , Lleó, Alberto
Alzheimer's & Dementia | April 25, 2025 | Volume: 21 | Issue: 4 | Pages: No page available
AbstractINTRODUCTIONSelf‐reported sex influences brain resilience, but its role in genetic frontotemporal dementia (FTD) remains unclear.METHODSWe analyzed 394 genetic‐FTD patients and 279 controls from the ALLFTD consortium, assessing annual neuropsychological performance and MRI‐based cortical thickness. Clinical characteristics and cortical thickness were compared between sexes. We used the residuals of linear regression models, which predict each participant's cognitive and behavioral performance levels relative to cortical thickness, as a proxy for reserve. We then modeled sex differences in longitudinal trajectories with linear mixed‐effects models.RESULTSSymptomatic females with genetic FTD had lower frontal cortical thickness than males, and the C9orf72 subgroup showed lower‐than‐expected frontal cortical thickness for a given level of executive functioning. Differences in cognitive reserve between sexes peaked near symptom onset but diminished thereafter.DISCUSSIONFemales with genetic FTD showed higher cognitive reserve than males, suggesting that self‐reported sex modulates resilience to frontotemporal neurodegeneration.Highlights Females with genetic FTD showed higher cognitive reserve than males. Those differences were particularly pronounced in the C9orf72 and GRN subgroups. The higher cognitive reserve in females declined as the disease progressed.