Citations 2
Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022
Kung, Che-Pei , Skiba, Meghan B. , Gorzelitz, Jessica , Lange, Leslie A. , Potiaumpai, Melanie , James, Dara , Galván, Gloria C. , Hornbuckle, Lyndsey M. , Kim, So‐Youn , Kim, Tae-Hyung , Kumar, Amanika , Mahé, Mélanie , Sun, Xinghui , Irwin, Melinda L. , Gorzelitz, Jessica , Li, Yun Rose , Potiaumpai, Melanie , Coleman, Michael F , Kumar, Amanika , Sun, Xinghui , Skiba, Meghan B , Crosby, Erika J. , Kennedy, Mary Ann , Kerr, Bethany A. , Nash, Sarah H. , Kleckner, Amber S. , Fairman, Ciaran M. , Garcia, David O. , Gordon, Max J. , His, Mathilde , McDonnell, Karen Kane , Moore, Jade , Oh, Sangphil
JNCI Monographs | May 4, 2023 | Volume: 2023 | Issue: 61 | Pages: 149-157
10.1093/jncimonographs/lgad005
Abstract The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives. Writing groups were formed and collaborated on this summary of the 5 key takeaways from the TREC Workshop. The 2022 TREC Workshop provided a targeted and unique networking opportunity that facilitated meaningful collaborative work addressing research and clinical needs in energetics and cancer. This report summarizes the 2022 TREC Workshop’s key takeaways and future directions for innovative transdisciplinary energetics and cancer research.
TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow–derived proangiogenic cell differentiation, function, and neovascularization
Wara, Akm Khyrul , Foo, ShiYin, Croce, Kevin , Sun, Xinghui , Icli, Basak , Tesmenitsky, Yevgenia, Esen, Fehim , Subramaniam, Malayannan , Spelsberg, Thomas C., Lev, Eli I. , Leshem‐Lev, Dorit, Pande, Reena L. , Rosenzweig, Anthony , Feinberg, Mark W. , Lee, Jungsoo , Creager, Mark A. , Rosenzweig, Anthony
Blood | August 9, 2011 | Volume: 118 | Issue: 24 | Pages: 6450-6460
Abstract Emerging evidence demonstrates that proangiogenic cells (PACs) originate from the BM and are capable of being recruited to sites of ischemic injury where they contribute to neovascularization. We previously determined that among hematopoietic progenitor stem cells, common myeloid progenitors (CMPs) and granulocyte-macrophage progenitor cells (GMPs) differentiate into PACs and possess robust angiogenic activity under ischemic conditions. Herein, we report that a TGF-β1–responsive Krüppel- like factor, KLF10, is strongly expressed in PACs derived from CMPs and GMPs, ∼ 60-fold higher than in progenitors lacking PAC markers. KLF10−/− mice present with marked defects in PAC differentiation, function, TGF-β responsiveness, and impaired blood flow recovery after hindlimb ischemia, an effect rescued by wild-type PACs, but not KLF10−/− PACs. Overexpression studies revealed that KLF10 could rescue PAC formation from TGF-β1+/− CMPs and GMPs. Mechanistically, KLF10 targets the VEGFR2 promoter in PACs which may underlie the observed effects. These findings may be clinically relevant because KLF10 expression was also found to be significantly reduced in PACs from patients with peripheral artery disease. Collectively, these observations identify TGF-β1 signaling and KLF10 as key regulators of functional PACs derived from CMPs and GMPs and may provide a therapeutic target during cardiovascular ischemic states.