Citations 1
Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol‐Associated Hepatitis: A Global Cohort Study
Idalsoaga, Francisco , Díaz, Luis Antonio , Guizzetti, Leonardo , Dunn, Winston , Arnold, Jorge , Ayares, Gustavo , Mortuza, Rokhsana , Mahli, Gurpreet, Islam, Alvi H. , Maiwall, Rakhi , Qian, Steve , Elfeki, Mohamed A. , Ramírez, Carolina , Higuera‐de‐la‐Tijera, Fátima , Al‐Karaghouli, Mustafa , Jalal, Prasun K. , Ibrahim, Mohamad Ali , García‐Tsao, Guadalupe , Havaj, Daniel Ján , Sulejova, Karolina, Shah, Vijay H. , Kamath, Patrick S. , Mehta, Heer , Arnold, Jorge , Ayares, Gustavo , Mortuza, Rokhsana , Sarin, Shiv Kumar , Maiwall, Rakhi , Qian, Steve , Simonetto, Douglas A , Singal, Ashwani K , Elfeki, Mohamed A , Ramirez-Cadiz, Carolina , Cabezas, Joaquín , Ventura Cots, Meritxell , Higuera-De La Tijera, Fatima , Abraldes, Juan G , Jalal, Prasun K , García-Tsao, Guadalupe , Skladaný, Lubomir , Havaj, Daniel J , Kamath, Patrick S , Arrese, Marco , Bataller, Ramon A , Arab, Juan P , Guizzetti, L , Díaz, Luis A , Dunn, Winston , Echavaría, Victor , Zhang, Wei , Simonetto, Douglas A. , Singal, Ashwani K. , Cabezas, Joaquín , Ventura‐Cots, Meritxell , Abraldeṣ, Juan G. , García–Tsao, Guadalupe , Goyes, Daniela , Selčanová, Světlana Adamcová , Rincón, Diego , Arrese, Marco , Arab, Juan Pablo
Alimentary Pharmacology & Therapeutics | February 19, 2025 | Volume: 61 | Issue: 8 | Pages: 1391-1395
ABSTRACTSeveral dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and short‐term mortality in severe AH within a global cohort. We conducted a multi‐national study of patients with severe AH treated with corticosteroids for at least 7 days, enrolled between 2009 and 2019. Dynamic models—Lille‐4, Lille‐7, trajectory of serum bilirubin (TSB), and neutrophil‐to‐lymphocyte ratio (NLR)—were used to estimate 30‐ and 90‐day mortality. Lille‐7 demonstrated the highest accuracy for both 30‐ and 90‐day mortality.