Citations 1
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis
AlAsfoor, Shefaa , Jessen, Erik , Pullapantula, Suraj R., Voisin, Jennifer R., Hsi, Linda C., Farwana, Samera, Patraw, Jack A., Chai, Xin-yi, Ji, Sihan , Strausbauch, Michael, Cipriani, Gianluca , Wei, Lai , Hou, Ruixue , Myers, R , Bhattarai, Yogesh , Wykosky, Jill, Burns, Alan J. , Dasari, Surendra , Farrugia, Gianrico , Grover, Madhusudan , Chai, Xinyi , Strausbauch, Michael A, Bhattarai, Y , Farrugia, Gianrico , Grover, Madhusudan , Chai, Xin-Yi , Pavelko, Kevin D. , Farwana, Samera, Chai, Xin-yi, Linden, David R.
American Journal of Physiology-Gastrointestinal and Liver Physiology | February 14, 2025 | Volume: 328 | Issue: 4 | Pages: G323-G341
Using 32 immune cell surface markers, we identified 23 monocyte clusters in murine blood. Diabetic gastroparesis was associated with a significant decrease in two circulating classical monocyte-like clusters and an upregulation of the Ccr2-Ccl2 axis in the gastric muscularis propria, suggesting increased tissue monocyte migration. This study offers new targets by pointing to a possible role for two classical monocyte subsets connected to the Ccr2- Ccl2 axis.