Citations 1
A new C-peptide minimal model to assess β-cell responsiveness to glucagon in individuals with and without type 2 diabetes
Boscolo, Francesca S. , Faggionato, Edoardo , Welch, Andrew A. , FARAHANI, RAHELE A., Egan, Aoife M. , Vella, Adrian , Man, Chiara Dalla , Boscolo, Federica , Dalla Man, Chiara , Vella, Adrian , Egan, A M
American Journal of Physiology-Endocrinology and Metabolism | February 10, 2025 | Volume: 328 | Issue: 3 | Pages: E470-E477
In this study, we propose a new mathematical model able to quantify C-peptide secretion and β-cell responsivity in response to a glucagon bolus in individuals without and with type 2 diabetes. We show that individuals with type 2 diabetes exhibit reduced β-cell responsivity to glucagon.