Clark, David A.
https://orcid.org/0000-0002-8334-492X
Mayo Clinic
Indiana University School of Medicine
Citations 2
Tablet‐based Cognitive Assessment Tool (TabCAT) in a multisite study of early‐onset Alzheimer's disease
Njamnshi, Wepnyu Yembe , Chiotis, Konstantinos , Tsoy, Elena , Blazhenets, Ganna , Maiti, Piyush , Zhang, J. , Allen, Isabel Elaine , Rocha, Salma, Shankar, Ranjani , Amuiri, Alinda, Lawson, Mawuli, Aisen, Paul , Eloyan, Ani , Hammers, Dustin B. , Kirby, Kala, Koeppe, Robert, Toga, Arthur W., Clark, David A. , Day, Gregory S. , Duara, Ranjan , Graff‐Radford, Neill R., Grant, Ian , Johnson, Erik C. B. , Masdeu, Joseph C. , Mendez, Mario F. , Onyike, Chiadi U. , Riddle, Meghan , Rogalskı, Emily , Salloway, Steven, Sha, Sharon J. , Turner, Raymond Scott , Wingo, Thomas S. , Kramer, Joel H. , Touroutoglou, Alexandra , Brickhouse, Michael , Jack, Clifford R. , Taurone, Alexander, Thangarajah, Maryanne, Carrillo, Marı́a C., Apostolova, Liana G. , Possin, Katherine L. , Rabinovici, Gil D. , Joie, Renaud La , Carrillo, María C. , Zhang, Jiaxiuxiu , Dickerson, Bradford Clark , La Joie, Renaud , Jack, Clifford R , Day, Gregory S , Rabinovici, Gil D , Blazhenets, Ganna , Wingo, Thomas S , Chiotis, Konstantinos , Rocha, Salma, Lawson, Mawuli, Beckett, Laurel , Hammers, Dustin B , Kirby, Kala, Kukull, Walter A. , Toga, Arthur W. , Atri, Alireza , Clark, David, Duara, Ranjan , Graff‐Radford, Neill R. , Honig, Lawrence S. , Jones, David T. , Masdeu, Joseph C , Musiek, Erik , Salloway, Steve , Wolk, David A. , Womack, Kyle , Vemuri, Prashanthi , Nudelman, Kelly
Alzheimer's & Dementia | December 15, 2025 | Volume: 21 | Issue: 12 | Pages: No page available
Abstract INTRODUCTION Brief digital cognitive measures may be a valuable and scalable alternative to traditional tests for improving early detection and disease monitoring in patients with early‐onset Alzheimer's disease (EOAD). METHODS We examined the convergent, diagnostic, and neuroanatomical validity of Tablet‐based Cognitive Assessment Tool (TabCAT) tests in the multisite Longitudinal Early‐Onset Alzheimer's Disease Study. Four hundred seventy‐five participants from 16 sites (83 cognitively unimpaired participants, 146 individuals diagnosed with mild cognitive impairment [MCI], and 246 with mild dementia) underwent TabCAT testing, including two executive/attentional tasks (Match and Flanker) and two visuospatial tasks (Line Length and Line Orientation). RESULTS TabCAT tests showed good convergent validity with traditional pen‐and‐paper tests. Match was the most accurate TabCAT test in differentiating among clinical groups (controls vs. MCI vs. dementia) and predicting amyloid positron emission tomography (PET) positivity in clinically impaired participants. TabCAT tests were associated with regional tau PET patterns. DISCUSSION TabCAT digital measures have promise for frontline identification of patients with EOAD. Highlights Four hundred seventy‐five participants from 16 US sites underwent tablet‐based cognitive assessment. Digital tests assessed executive function and visuospatial abilities. Digital tests correlated with traditional pen‐and‐paper cognitive tests. Match (test of executive function) differentiated clinical groups. Digital tests were associated with amyloid positron emission tomography (PET) status and regional tau PET patterns.
Differences in baseline cognitive performance between participants with early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI
Hammers, Dustin B. , Eloyan, Ani , Thangarajah, Maryanne, Taurone, Alexander, Gao, Sujuan , Polsinelli, Angelina J. , Kirby, Kala, Dage, Jeffrey L. , Aisen, Paul , Reman, Rema, Joie, Renaud La , Clark, David A. , Day, Gregory S. , Duara, Ranjan , Graff‐Radford, Neill R. , Masdeu, Joseph C. , Mendez, Mario F. , Onyike, Chiadi U. , Riddle, Meghan , Grant, Ian , Rogalskı, Emily , Johnson, Erik C. B. , Salloway, Steven, Sha, Sharon J. , Turner, Raymond Scott , Wingo, Thomas S. , Carrillo, María C. , Rabinovici, Gil D. , Apostolova, Liana G. , Day, Gregory S , La Joie, Renaud , Rabinovici, Gil D , Wingo, Thomas S , Dage, Jeffrey L , Hammers, Dustin B , Beckett, Laurel , Kirby, Kala, Nudelman, Kelly , Lagarde, Julien , Atri, Alireza , Clark, David, Duara, Ranjan , Honig, Lawrence S. , Jones, David T. , Masdeu, Joseph C , Womack, Kyle , Musiek, Erik , Salloway, Steve , Wolk, David A. , Dickerson, Bradford Clark
Alzheimer's & Dementia | December 23, 2024 | Volume: 21 | Issue: 1 | Pages: No page available
Abstract INTRODUCTION Early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller‐scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD. METHODS Z‐ score cognitive‐domain composites for 311 amyloid‐positive sporadic EOAD and 314 amyloid‐positive LOAD participants were calculated from baseline data from age‐appropriate control cohorts. Z‐ score composites were compared between AD groups for each domain. RESULTS After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate memory, and episodic delayed memory. DISCUSSION Sporadic EOAD possesses distinct cognitive profiles relative to LOAD. Clinicians should be alert for non‐amnestic impairments in younger patients to ensure proper identification and intervention using disease‐modifying treatments. Highlights Both early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD) participants displayed widespread cognitive impairments relative to their same‐aged peers. Cognitive impairments were more severe for EOAD than for LOAD participants in visuospatial and executive domains. Memory and language impairments were more severe for LOAD than for EOAD participants Results were comparable after removing clinical phenotypes of posterior cortical atrophy (PCA), primary progressive aphasia (lv‐PPA), and frontal‐variant AD.