Citations 1
Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver
Zhu, Xiaohui, Yang, Yan , Feng, Dongfeng , Wang, Oliver , Chen, Jiaxiang , Wang, Jiale , Liu, Yang , Edenfield, Brandy , Haddock, Ashley , Bi, Yan , Ji, Baoan , Edenfield, Brandy H, Haddock, Ashley N, Bi, Yan , Ji, Baoan , Wang, Jiale , Zhu, Xiaohui, Wang, Oliver, Wang, Bin , Wang, Ying , Patel, Tushar
American Journal of Physiology-Gastrointestinal and Liver Physiology | March 12, 2024 | Volume: 326 | Issue: 5 | Pages: G495-G503
A liver-specific Alb-FlpO mouse line was generated. By coupling it with other existing CreERT or Cre lines, the dual recombinase approach can enable sequential gene modifications within the same cell or across various cell types in an organism for liver research through temporal and spatial gene manipulations.