Coppola, Giovanni
https://orcid.org/0000-0003-2105-1061
Mayo Clinic
University of California, Los Angeles
Citations 40
O4‐03‐01: FRONTOTEMPORAL LOBAR DEGENERATION RESEARCH IN NORTH AMERICA: PROGRESS IN THE ARTFL/LEFFTDS CONSORTIA
Heuer, Hilary W. , Boxer, Adam L. , Rosen, Howard J. , Forsberg, Leah K. , Brushaber, Danielle , Bordelon, Yvette , Coppola, Giovanni , Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff-Radford, N. R., Grant, Ian , Huey, Edward D. , Karydas, Anna M., Kaufer, Daniel , Kramer, Joel H. , Ljubenkov, Peter A. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , McGinnis, Scott M., Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Pearlman, Rodney , Petrucelli, Leonard , Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Rogalskı, Emily , Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Weıntraub, Sandra , Consortia, ARTFL and LEFFTDS, Boeve, Bradley F. , Appleby, Brian S. , Brannelly, Patrick , Domoto‐Reilly, Kimiko , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wong, Bonnie , Wszołek, Zbigniew K. , Consortia, ARTFL and LEFFTDS
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_23 | Pages: No page available
P2‐397: GYRIFICATION ABNORMALITIES IN PRESYMPTOMATIC C9ORF72 EXPANSION CARRIERS
Lee, Suzee E. , Battistella, Giovanni , Chu, Stephanie A. , Rosen, Howard J. , Karydas, Anna M., Coppola, Giovanni , Geschwind, Daniel H. , Rademakers, Rosa , Tempini, Maria Luisa Gorno , Caverzasi, Eduardo , Zanto, Theodore P. , Miller, Bruce L. , Seeley, William W.
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available
P2‐329: TRACKING WHITE MATTER DEGENERATION IN ASYMPTOMATIC AND SYMPTOMATIC MAPT MUTATION CARRIERS WITH DTI
Tosakulwong, Nirubol , Lesnick, Timothy G. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boxer, Adam L. , Rosen, Howard J. , Chen, Qin , Boeve, Bradley F. , Schwarz, Christopher G. , Reid, Robert I. , Brannelly, Patrick , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jack, Clifford R. , Jones, David T. , Jones, Lynne, Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wong, Bonnie , Wszołek, Zbigniew K. , Kantarci, Kejal
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available
O2‐14‐06: DIFFERENCES BETWEEN SPORADIC AND FAMILIAL BEHAVIORAL VARIANT FTD IN ADVANCING RESEARCH AND TREATMENT FOR FTLD (ARTFL) CLINICAL RESEARCH CONSORTIUM
Boxer, Adam L. , Heuer, Hilary W. , Wang, Ping , Rascovsky, Katya, Rosen, Howard J. , Coppola, Giovanni , Dickerson, Brad C., Bordelon, Yvette , Faber, Kelley, Fields, Julie A. , Ghoshal, Nupur , Graff-Radford, N. R., Huey, Edward D. , Kaufer, Daniel , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lungu, Codrin , Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Rademakers, Rosa , Sutherland, Marg, Weıntraub, Sandra , Rogalskı, Emily , Wang, Ping, Boeve, Bradley F. , Grossman, Murray , Domoto‐Reilly, Kimiko , Feldman, Howard , Fong, Jamie , Foroud, Tatiana , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_12 | Pages: No page available
O2‐14‐01: CHARACTERISTICS AND PROGRESS OF 320 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL
Forsberg, Leah K. , Rosen, Howard J. , Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott M., Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Sutherland, Marg, Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_12 | Pages: No page available
O1‐08‐01: THE NIH‐EXAMINER IS SENSITIVE TO COGNITIVE CHANGES IN ASYMPTOMATIC AND MILDLY SYMPTOMATIC FAMILIAL FRONTOTEMPORAL DEMENTIA
Staffaroni, Adam M. , Bajorek, Lynn, Ljubenkov, Peter A. , Casaletto, Kaitlin B. , Rascovsky, Katya, Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Radford, Jonathan Graff, Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Sutherland, Margaret , Syrjanen, Jeremy A. , Taylor, Joanne, Weıntraub, Sandra , Rosen, Howard J. , Kramer, Joel H. , Elahi, Fanny M. , Boeve, Bradley F. , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_4 | Pages: No page available
P1‐433: GRAY MATTER DEFICITS IN SYMPTOMATIC AND PRESYMPTOMATIC MAPT MUTATION CARRIERS
Chu, Stephanie A. , Flagan, Taru , Papma, Janne M. , Deng, Jersey, Rosen, Howard J. , Boxer, Adam L. , Heuer, Hilary W. , Brushaber, Danielle , Coppola, Giovanni , Dickerson, Brad C., Bordelon, Yvette , Dheel, Christina, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Huey, Edward D. , Kaufer, Daniel , Karydas, Anna M., Klein, Alex, Kornak, John , Kramer, Joel H. , Laxineta, Samara, Mackenzie, Ian R. , Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Potter, Madeline, Rademakers, Rosa , Tatton, Nadine , Vetor, Ashley, Weıntraub, Sandra , Lee, Suzee E. , Jiskoot, Lize C. , Seeley, William W. , Boeve, Bradley F. , Grossman, Murray , Feldman, Howard , Fong, Jamie , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Klein, Alex, Knopman, David S. , Kukull, Walter A. , Lapid, Maria I. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K. , Swieten, John C. van
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_8 | Pages: No page available
P1‐419: USING A BRAIN NETWORK APPROACH TO PREDICT GENETIC MUTATION IN INDIVIDUAL PATIENTS WITH FAMILIAL FRONTOTEMPORAL DEMENTIA
Touroutoglou, Alexandra , Brickhouse, Michael , Krivensky, Samantha, Getchell, Katelynn, Lucente, Diane , McGinnis, Scott M., Dickerson, Brad C., Rosen, Howard J. , Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickinson, Susan, Faber, Kelley, Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Grossman, Murray, Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Mackenzie, Ian R. , Manoochehri, Masood , Pearlman, Rodney , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Hsiao, John , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_8 | Pages: No page available
P1‐281: NONLINEAR N‐SCORE ESTIMATION FOR ESTABLISHING COGNITIVE NORMS FROM THE NATIONAL ALZHEIMER'S COORDINATING CENTER (NACC) DATASET
Kornak, John , Fields, Julie A. , Farmer, Sarah, Rosen, Howard J. , Boxer, Adam L. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kramer, Joel H. , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Rankin, Katherine , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Jones, Lynne, Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_7 | Pages: No page available
Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers
Meeter, Lieke , Sias, Ana C. , Jiskoot, Lize C. , Kaat, Laura Donker , Papma, Janne M., Panman, Jessica , Ende, Emma L. van der , Dopper, Elise G.P. , Graff, Caroline , Boxer, Adam L. , Rosen, Howard J., Sánchez‐Valle, Raquel , Galimberti, Daniela , Pijnenburg, Yolande A.L. , Benussi, Luisa , Ghidoni, Roberta , Borroni, Barbara , Laforce, Robert , Campo, Marta del , Teunissen, Charlotte E. , Minkelen, Rick van , Coppola, Giovanni , Geschwind, Dan, Rademakers, Rosa , Karydas, Anna M., Öijerstedt, Linn , Binetti, Giuliano , Padovani, Alessandro , Cash, David M. , Dick, Katrina M., Bocchetta, Martina , Rohrer, Jonathan D. , Petrucelli, Leonard , Lee, Suzee E. , Gendron, Tania F. , Del Campo, Marta , Teunissen, Charlotte E , Sánchez-Valle, Raquel , Rohrer, Jonathan D , Russo, Silvia P. , Papma, Janne M. , Franzen, Sanne , Rojas, Julio C. , Scarpini, Elio , Miller, Bruce L. , Swieten, John C. van , Padovani, Alessandro , Cash, David M , Donker Kaat, Laura , Dopper, Elise G P , Galimberti, Daniela , Bocchetta, Martina , Pijnenburg, Yolande A L , Jiskoot, Lize C , Laforce, Robert , Graff, Caroline , Borroni, Barbara
Annals of Clinical and Translational Neurology | April 10, 2018 | Volume: 5 | Issue: 5 | Pages: 583-597
AbstractObjectiveTo evaluate poly(GP), a dipeptide repeat protein, and neurofilament light chain (NfL) as biomarkers in presymptomatic C9orf72 repeat expansion carriers and patients with C9orf72‐associated frontotemporal dementia. Additionally, to investigate the relationship of poly(GP) with indicators of neurodegeneration as measured by NfL and grey matter volume.MethodsWe measured poly(GP) and NfL levels in cerebrospinal fluid (CSF) from 25 presymptomatic C9orf72 expansion carriers, 64 symptomatic expansion carriers with dementia, and 12 noncarriers. We explored associations with grey matter volumes using region of interest and voxel‐wise analyses.ResultsPoly(GP) was present in C9orf72 expansion carriers and absent in noncarriers (specificity 100%, sensitivity 97%). Presymptomatic carriers had lower poly(GP) levels than symptomatic carriers. NfL levels were higher in symptomatic carriers than in presymptomatic carriers and healthy noncarriers. NfL was highest in patients with concomitant motor neuron disease, and correlated with disease severity and survival. Associations between poly(GP) levels and small grey matter regions emerged but did not survive multiple comparison correction, while higher NfL levels were associated with atrophy in frontotemporoparietal cortices and the thalamus.InterpretationThis study of C9orf72 expansion carriers reveals that: (1) poly(GP) levels discriminate presymptomatic and symptomatic expansion carriers from noncarriers, but are not associated with indicators of neurodegeneration; and (2) NfL levels are associated with grey matter atrophy, disease severity, and shorter survival. Together, poly(GP) and NfL show promise as complementary biomarkers for clinical trials for C9orf72‐associated frontotemporal dementia, with poly(GP) as a potential marker for target engagement and NfL as a marker of disease activity and progression.