Piña‐Escudero, Stefanie Danielle
https://orcid.org/0000-0001-7467-8365
Mayo Clinic
University of California, San Francisco
Citations 2
Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City
Brucki, Sonia MD, Acosta, Daisy M, Carrillo, María C. , Mendez, Patricio Alexis Chrem , Cornejo‐Olivas, Mario , Custodio, Nilton , Duran‐Aniotz, Claudia , García, A.R. , Gonzales, Mitzi M. , Grinberg, Lea T. , Illanes‐Manrique, Maryenela , Jack, Clifford R. , Leon‐Salas, Jorge M, Luna‐Muñoz, José , Pericak‐Vance, Margaret A. , Resende, Elisa de Paula França , Ringman, John M. , Suemoto, Cláudia Kimie , Valcour, Victor , Villegas‐Lanau, Andrés, Sexton, Claire E. , Mahinrad, Simin , Sexton, Claire , Jack, Clifford R , Cornejo-Olivas, Mario , Grinberg, Lea , Suemoto, Claudia Kimie , Gonzales, Mitzi , Sosa, Ana Luisa , Crivelli, Lucía , Lopera, Francisco Javier , Acosta‐Uribe, Juliana , Aguilar, Diego, Aguilar-Navarro, Sara G. , Allegri, Ricardo , Bertolucci, Paulo Henrique Ferreira , Calandri, Ismael Luis , Damián, Andrés , Souza, Leonardo Cruz de , García‐Peña, Carmen , Ibáñez, Agustín , Llibre‐Guerra, Jorge J. , Matallana, Diana , Miller, Bruce L. , Naçi, Lorina , Parra, Mario A. , Piña‐Escudero, Stefanie Danielle , Sevlever, Gustavo Emilio , Slachevsky, Andrea , Yassuda, Mônica Sanches , Mahinrad, Simin
Alzheimer's & Dementia | May 27, 2024 | Volume: 20 | Issue: 7 | Pages: 5009-5026
AbstractINTRODUCTIONWhile Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care.METHODSIn 2023, the Alzheimer's Association hosted its eighth satellite symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm.RESULTSSignificant initiatives in the region, including intracountry support, showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; researchers conducting emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care, and use affordable biomarkers in the region was highlighted.DISCUSSIONThe myriad of topics discussed at the 2023 AAIC satellite symposium highlighted the growing research efforts in LatAm, providing valuable insights into dementia biology, genetics, epidemiology, treatment, and care.
APOE and immunity: Research highlights
Kloske, Courtney M. , Barnum, Christopher J. , Batista, André F., Bradshaw, Elizabeth M. , Bu, Guojun , Dennison, Jessica , Gearon, Mary D, Goate, Alison , Haass, Christian , Hu, William T. , Huggins, Lenique , Jones, Nahdia S. , Liddelow, Shane A. , Marsh, Samuel E. , Petersen, Melissa, Piña‐Escudero, Stefanie Danielle , Reiman, Eric M. , Sexton, Claire E. , TCW, Julia , Wallings, Rebecca L. , Weninger, Stacie, Wharton, Whitney , Wishard, Tyler J. , Worley, Susan, Carrillo, María C. , Sexton, Claire , Bu, Guojun , Goate, Alison M , Hu, William T. , Brickman, Adam M. , Heneka, Michael T. , Koldamova, Radosveta P. , Lemere, Cynthia Ann , Marcora, Edoardo , Nielsen, Henrietta M. , Petersen, Kellen K. , Petersen, Melissa , Qiu, Wei Qiao , Quiroz, Yakeel T. , Tansey, Malú G. , Teunissen, Charlotte E. , Tijms, Betty M. , Kant, Rik van der , Wilcock, Donna M. , Zetterberg, Henrik
Alzheimer's & Dementia | March 28, 2023 | Volume: 19 | Issue: 6 | Pages: 2677-2696
AbstractINTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.RESULTSDuring the 4‐day meeting, presenters illuminated aspects of the cross‐talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.