Citations 1
IgA vasculitis nephritis (Schönlein-Henoch purpura with nephritis) following COVID-19 vaccination
Mahmoodnia, Leila , Savadjani, Shahin Asgari , Mostafavi, Leila , Korani, Setayesh Sotoudehnia , Chafjiri, Fatemeh Mohammad Alizadeh , Moghadam, Mahshid Sadat Chenarani , Jahantigh, Hamid Reza , Neshat, Sina , Shirbacheh, Ali , Baharani, Jyoti , Masomi, Rohollah , Hotkani, Zahra Golestani , Sotoudehnia, Setayesh
Journal of Nephropathology | February 15, 2023 | Volume: No volume available | Issue: No issue available | Pages: No page available
IgA vasculitis nephritis (Schönlein-Henoch purpura nephritis) is an autoimmune circumstance characterized by palpable purpura involving the lower limbs, arthralgia, abdominal pain and kidney involvement. It is possible that a cytokine storm following coronavirus disease 2019 (COVID-19) could lead to an immunological dysregulation responsible for IgA vasculitis nephritis in these cases. Reactivation or first onset of IgA vasculitis nephritis is uncommon; however, there have been increasing reports of this disease, as a complication of COVID-19 vaccination. It is possible that COVID-19 mRNA vaccination may trigger several auto-inflammatory and autoimmune cascades. Previous research has shown that Toll-like receptors play a role in the development of IgA vasculitis nephritis. Following injection of a COVID-19 mRNA vaccine, the uptake of double-stranded RNA by-products will trigger Toll-like receptors, leading to a series of intracellular cascades starting an innate immunity-driven process of cell-mediated and humoral- mediated immunity.