Guimarães, Alexander R.
https://orcid.org/0000-0003-4601-9340
Mayo Clinic
Oregon Health & Science University
Citations 2
Summary from the 2025 International Society for Magnetic Resonance in Medicine workshop on body MRI : Unsolved problems and unmet needs
Hecht, Elizabeth M. , Hu, Peng , Wu, Holden H. , Guimarães, Alexander R. , Ringe, Kristina I. , Syed, Ali , Group, on behalf of the ISMRM Body MRI Study, Hu, Houchun Harry , Serai, Suraj D , Wu, Holden H , Serai, Suraj D. , Brunsing, Ryan L. , Kurugol, Sila , Group, on behalf of the ISMRM Body MRI Study
Magnetic Resonance in Medicine | September 4, 2025 | Volume: 95 | Issue: 1 | Pages: 74-85
Abstract In March of 2025, 145 attendees convened at the Hub for Clinical Collaboration of the Children's Hospital of Philadelphia for the inaugural International Society for Magnetic Resonance in Medicine (ISMRM) Body MRI Study Group workshop entitled “Body MRI: Unsolved Problems and Unmet Needs.” Approximately 24% of the attendees were MD or MD/PhD's, 45% were PhD's, and 30% were early‐career trainees and postdoctoral associates. Among the invited speakers and moderators, 28% were from outside the United States, with a 40:60% female‐to‐male ratio. The 2.5‐day program brought together a multidisciplinary group of scientists, radiologists, technologists, and trainees. Session topics included quantitative imaging biomarkers, low‐ and high‐field strengths, artifact and motion correction, rapid imaging and focused protocols, and artificial intelligence. Another key session focused on the importance of team science and allowed speakers from academia and industry to share their personal experiences and offer advice on how to successfully translate new MRI technology into clinical practice. This article summarizes key points from the event and perceived unmet clinical needs within the field of body MRI.
Radiotherapy reimagined: Integrating nanomedicines into radiotherapy clinical trials
DuRoss, Allison N., Guimarães, Alexander R. , Baas, Carole , Krishnan, Sunil , Thomas, Charles R., Sun, Conroy , Bagley, Alexander F. , Krishnan, Sunil , Sun, Conroy , Bagley, Alexander F , Phan, Jack , Lazar, Alexander J. , Walker, Joshua M.
WIREs Nanomedicine and Nanobiotechnology | October 29, 2022 | Volume: 15 | Issue: 3 | Pages: No page available
AbstractRadioenhancing nanoparticles (NPs) are being evaluated in ongoing clinical trials for various cancers including head and neck, lung, esophagus, pancreas, prostate, and soft tissue sarcoma. Supported by decades of preclinical investigation and recent randomized trial data establishing clinical activity, these agents are poised to influence future multimodality treatment paradigms involving radiotherapy. Although the physical interactions between NPs and ionizing radiation are well characterized, less is known about how these agents modify the tumor microenvironment, particularly regarding tumor immunogenicity. In this review, we describe the key multidisciplinary considerations related to radiation, surgery, immunology, and pathology for designing radioenhancing NP clinical trials.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease