Citations 1
Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers
Weiner, Michael W. , Harvey, Danielle , Landau, Susan, Veitch, Dallas P. , Aisen, Paul, Petersen, Ronald C. , Tosun, Duygu , Shaw, Leslie M. , Trojanowski, John Q. , Saykin, Andrew J. , Carli, Charles De, DeCarli, Charles , Tosun, Duygu , DeCarli, Charles , Saykin, Andrew J , Harvey, Danielle J , Tosun, Duygu , Neylan, Thomas C. , Grafman, Jordan Henry , Jack, Clifford R. , Hayes, Jacqueline
Alzheimer's & Dementia | June 29, 2022 | Volume: 19 | Issue: 3 | Pages: 884-895
AbstractIntroductionEpidemiological studies report an association between traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker‐defined AD.MethodsWe identified 289 non‐demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aβ) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years.ResultsExposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P < .0001) and worse Mini‐Mental State Examination scores (PTSD: P = .008; TBI & PTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aβ or tau accumulation, or in most longitudinal measures.DiscussionTBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.