Citations 3
OCT-Based Differentiation of First Acute Optic Neuritis
Pakeerathan, Thivya , Davis, James , Sotirchos, Elias S. , Said, Yana , Havla, Joachim , Ringelstein, Marius, Aktas, Orhan, Weise, Margit, Gernert, Jonathan A. , Bsteh, Gabriel , Rommer, Paulus , Pröbstel, Anne-Katrin, Kulsvehagen, Laila , Pretzsch, Roxanne , Schoenholzer, Kean , Padungkiatsagul, Tanyatuth , Moss, Heather E. , Navarro, Sylvia E. Villarreal , Herwerth, Marina , Graure, Madalina, Kana, Veronika , Stiebel-Kalish, Hadas, Zlatkin, Rita , Arnold, Anthony C. , Bonelli, Laura , Stellmann, Jan-Patrick, Stolowy, Natacha , Schneider-Gold, Christiane, Kümpfel, Tania, Philipp, A, Pittock, S., Ayzenberg, I., Henderson, Amanda D , Sotirchos, Elias S , Said, Yana , Havla, Joachim , Ringelstein, Marius , Aktas, Orhan , Gernert, Jonathan A , Kornek, Barbara , Bsteh, Gabriel , Rommer, Paulus S , Krajnc, Nik , Pröbstel, Anne-Katrin , Papadopoulou, Athina , Kulsvehagen, Laila , Pretzsch, Roxanne , Schoenholzer, Kean , Padungkiatsagul, Tanyatuth , Moss, Heather E , Villarreal Navarro, Sylvia E , Herwerth, Marina , Graure, Madalina , Kana, Veronika , Stiebel-Kalish, Hadas , Arnold, Anthony C , Bonelli, Laura , Stellmann, Jan-Patrick , Stolowy, Natacha , Schwake, Carolin , Schneider-Gold, Christiane , Kuempfel, Tania , Albrecht, Philipp , Rattanathamsakul, Natthapon , Pittock, S J , Flanagan, E P , Carta, Sara , Mariotto, Sara , Gold, Ralf , Chen, John J , Ayzenberg, Ilya , Henderson, Amanda D. , Ringelstein, Marius , Aktaş, Orhan , Stiebel‐Kalish, Hadas , Kümpfel, Tania , Rattanathamsakul, Natthapon , Pittock, Sean J. , Flanagan, Eoin P. , Carta, Sara , Mariotto, Sara , Chen, John J. , Ayzenberg, Ilya
Neurology Neuroimmunology & Neuroinflammation | January 7, 2026 | Volume: 13 | Issue: 2 | Pages: No page available
Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network
Klyscz, Philipp , Asseyer, Susanna , Bereuter, Charlotte , Bialer, Omer , Bick, Atira, Carta, Sara , Chen, John J. , Cohen, Leila , Cohen‐Tayar, Yamit , Gernert, Jonathan A. , Haas, Julian , Heesen, Christoph , Hellmann, Mark A. , Levin, Netta , Lotan, Itay , Luis, María Belén , Vergara, Alvaro Jose Mejia, Ocampo, Cassandra, Ochoa, Susana, Oertel, Frederike Cosima , Olszewska, Maja, Uribe, José Luis Peralta , Scocco, Darío H. , Shifa, Jemal Zeberga, Simantov, Ilya, Tiosano, Alon , Torres-Camacho, Isabel , Dembinsky, Adi Vaknin, Vidal‐Jordana, Ángela , Wilf‐Yarkoni, Adi , Wu, Ti , Zamir, Sol, Zarco, Luis Alfonso , Zimmermann, Hanna , Paul, Friedemann , Dale, Russell C , Levin, Netta , Lotan, Itay , Mariotto, Sara , Oertel, Frederike C , Sastre-Garriga, Jaume , Ramanathan, Sudarshini , Rattanathamsakul, Natthapon , Shi, Fu-Dong , Tisavipat, Nanthaya , Zimmermann, Hanna G , Paul, Friedemann , Chen, John J , Carta, Sara , Alonso, Ricardo Nicolás , Contentti, Edgar Carnero , Dale, Russell C. , Flanagan, Eoin P. , Haas, Julian, Havla, Joachim , López, Pablo A. , Mariotto, Sara , Mayer, Christina , Mejía-Vergara, Álvaro J. , Ramanathan, Sudarshini , Rattanathamsakul, Natthapon , Siritho, Sasitorn , Tisavipat, Nanthaya , Petzold, Axel , Stiebel‐Kalish, Hadas
Annals of Clinical and Translational Neurology | August 5, 2024 | Volume: 11 | Issue: 9 | Pages: 2473-2484
AbstractObjectiveThe first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these criteria to a prospective, global observational study of acute optic neuritis (ON).MethodsWe included 160 patients with a first‐ever acute ON suggestive of a demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). We applied the 2022 ICON to all participants and subsequently adjusted the ICON by replacing a missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology of the optical nerve plus optical coherence tomography abnormalities or certain biomarkers are present.ResultsAccording to the 2022 ICON, 80 (50%) patients were classified as definite ON, 12 (7%) patients were classified as possible ON, and 68 (43%) as not ON (NON). The main reasons for classification as NON were absent RAPD (52 patients, 76%) or dyschromatopsia (49 patients, 72%). Distribution of underlying ON etiologies was as follows: 78 (49%) patients had a single isolated ON, 41 (26%) patients were diagnosed with multiple sclerosis, 25 (16%) patients with myelin oligodendrocyte glycoprotein antibody‐associated disease, and 15 (9%) with neuromyelitis optica spectrum disorder. The application of the adjusted ON criteria yielded a higher proportion of patients classified as ON (126 patients, 79%).InterpretationAccording to the 2022 ICON, almost half of the included patients in ACON did not fulfill the requirements for classification of definite or possible ON, particularly due to missing RAPD and dyschromatopsia. Thorough RAPD examination and formal color vision testing are critical to the application of the 2022 ICON.
Longitudinal Retinal Changes in MOGAD
Oertel, Frederike Cosima , Sotirchos, Elias S. , Zimmermann, Hanna , Motamedi, Seyedamirhosein , Specovius, Svenja , Asseyer, Eva Susanna, Chien, Claudia , Cook, Lawrence J. , Vasileiou, Eleni S. , Filippatou, Angeliki , D’Cunha, Anitha , Pittock, Sean J. , Bhatti, M. Tariq , Rommer, Paulus , Bsteh, Gabriel , Zrzavy, Tobias , Kuempfel, Tania, Aktaş, Orhan , Ringelstein, Marius , Ayzenberg, Ilya , Pakeerathan, Thivya , Knier, Benjamin , Asgari, Nasrin , Soelberg, Kerstin , Marignier, Romain , Tilikete, Caroline , Calvo, Álvaro Cobo, Villoslada, Pablo , Sánchez‐Dalmau, Bernardo , Green, Ari , Brandt, Alexander U. , Chen, John , Paul, Friedemann , Palace, Jacqueline , Chen, John J. , Asseyer, Susanna , Huda, Saif , Zimmermann, Hanna G , Vasileiou, Eleni , Calabresi, Peter A , Pandit, Lekha , Zéphir, Hélène , Pittock, S J , Bsteh, Gabriel , Zrzavy, Tobias , Kuempfel, Tania , Ringelstein, Marius , Albrecht, Philipp , Knier, Benjamin , Aly, Lilian , Marignier, Romain , Villoslada, Pablo , Brandt, Alexander U , Paul, Friedemann , Chen, John J , Sotirchos, Elias S , Oertel, Frederike C , Palace, Jacqueline , Rommer, Paulus S , Filippatou, Angeliki G , Cook, Lawrence J , Calabresi, Peter A. , Saidha, Shiv , Pandit, Lekha , Outteryck, Olivier , Flanagan, Eoin P. , Kümpfel, Tania , Martínez‐Lapiscina, Elena H. , Llufriú, Sara , Yeaman, Michael R , Smith, Terry J. , Havla, Joachim
Annals of Neurology | June 15, 2022 | Volume: 92 | Issue: 3 | Pages: 476-485
ObjectivePatients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can be detected in MOGAD.MethodsEighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high‐definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified.ResultsAt baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD‐ON) compared with MOGAD eyes without a history of ON (MOGAD‐NON) and HCs (p < 0.001). MOGAD‐NON eyes had lower GCIPL volume compared to HCs (p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow‐up up to 3 years), MOGAD‐ON with ON within the last 6–12 months before baseline exhibited greater pRNFL thinning than MOGAD‐ON with an ON greater than 12 months ago (p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort.InterpretationOur study suggests the absence of attack‐independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476–485