Citations 2
Clinical Outcomes and Severity of Acute Respiratory Distress Syndrome in 1154 COVID-19 Patients: An Experience Multicenter Retrospective Cohort Study
Mutair, Abbas Al , Alhumaid, Saad , Layqah, Laila , Shamou, Jinan , Ahmed, Gasmelseed Y. , Chagla, Hiba Hameed , Alsalman, Khulud, Alnasser, Fadhah Mohammed, Alhuqbani, Waad N., Alghadeer, Mohammed , Mohaini, Mohammad Al , Almahmoud, Sana , Al‐Tawfiq, Jaffar A. , Muhammad, Javed , Al‐Jamea, Lamiaa H. , Woodman, Alexander, Alsaleh, Ahmed, Alsedrah, Abdulaziz M., Alharbi, Hanan Fahad , Saha, Chandni, Rabaan, Ali A. , Alhumaid, Saad , Rabaan, Ali A , Koritala, Thoyaja , Alghadeer, Mohammed
COVID | August 1, 2022 | Volume: 2 | Issue: 8 | Pages: 1102-1115
Background: Acute Respiratory Distress Syndrome (ARDS) is caused by non-cardiogenic pulmonary edema and occurs in critically ill patients. It is one of the fatal complications observed among severe COVID-19 cases managed in intensive care units (ICU). Supportive lung-protective ventilation and prone positioning remain the mainstay interventions. Purpose: We describe the severity of ARDS, clinical outcomes, and management of ICU patients with laboratory-confirmed COVID-19 infection in multiple Saudi hospitals. Methods: A multicenter retrospective cohort study was conducted of critically ill patients who were admitted to the ICU with COVID-19 and developed ARDS. Results: During our study, 1154 patients experienced ARDS: 591 (51.2%) with severe, 415 (36.0%) with moderate, and 148 (12.8%) with mild ARDS. The mean sequential organ failure assessment (SOFA) score was significantly higher in severe ARDS with COVID-19 (6 ± 5, p = 0.006). Kaplan–Meier survival analysis showed COVID-19 patients with mild ARDS had a significantly higher survival rate compared to COVID-19 patients who experienced severe ARDS (p = 0.023). Conclusion: ARDS is a challenging condition complicating COVID-19 infection. It carries significant morbidity and results in elevated mortality. ARDS requires protective mechanical ventilation and other critical care supportive measures. The severity of ARDS is associated significantly with the rate of death among the patients.
Updates on Measles Incidence and Eradication: Emphasis on the Immunological Aspects of Measles Infection
Rabaan, Ali A. , Mutair, Abbas Al , Alhumaid, Saad , Garout, Mohammed , Alsubki, Roua A. , Alshahrani, Fatimah , Alfouzan, Wadha , Alestad, Jeehan H., Alsaleh, Abdullah E., Al-Mozaini, Maha , Koritala, Thoyaja , Alotaibi, Sultan , Temsah, Mohamad‐Hani , Akbar, Ali , Ahmad, Rafiq , Khalid, Zainab , Muhammad, Javed , Ahmed, Naveed , Alfouzan, Wadha A , Alhumaid, Saad , Rabaan, Ali A
Medicina | May 20, 2022 | Volume: 58 | Issue: 5 | Pages: 680
Measles is an RNA virus infectious disease mainly seen in children. Despite the availability of an effective vaccine against measles, it remains a health issue in children. Although it is a self-limiting disease, it becomes severe in undernourished and immune-compromised individuals. Measles infection is associated with secondary infections by opportunistic bacteria due to the immunosuppressive effects of the measles virus. Recent reports highlight that measles infection erases the already existing immune memory of various pathogens. This review covers the incidence, pathogenesis, measles variants, clinical presentations, secondary infections, elimination of measles virus on a global scale, and especially the immune responses related to measles infection.