Citations 2
Age-associated differences in the human lung extracellular matrix
Ngassie, Maunick Lefin Koloko , Vries, Maaike de , Borghuis, Theo, Timens, Wim , Nickle, David C. , Marko‐Varga, György , Teske, Jacob J. , Burgess, Janette K. , Brandsma, Corry‐Anke , Koloko Ngassie, Maunick Lefin , Sin, Don D , Horvatovich, Peter , Teske, Jacob J , Vonk, Judith M , Gosens, Reinoud , Prakash, Y S , Burgess, Janette K , Brandsma, Corry-Anke , Timens, Wim , Joubert, Philippe , Vonk, Judith M. , Gosens, Reinoud , Prakash, Y. S.
American Journal of Physiology-Lung Cellular and Molecular Physiology | April 11, 2023 | Volume: 324 | Issue: 6 | Pages: L799-L814
We identified seven age-associated extracellular matrix (ECM) proteins, i.e., COL1A1, COL6A1, COL6A2 COL14A1, FBLN2, LTBP4, and LUM with higher transcript and protein levels in human lung tissue with age. Extensive immunohistochemical analysis revealed significant age-associated differences for COL6A2 in whole tissue, parenchyma, airway wall, and vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in parenchyma. Our findings lay a new foundation for the investigation of ECM differences in age-associated chronic lung diseases.
Age-Associated Changes in the Human Lung Extracellular Matrix
Ngassie, Maunick Lefin Koloko , Borghuis, Theo, Vries, M. de , Sin, Danielle, Joubert, Phillipe, Marko‐Varga, György , Koloko Ngassie, Maunick Lefin , Vries, M. De, Timens, Wim , Sin, D.D., Nickle, David C. , Horvatovich, Peter , Gosens, Reinoud , Prakash, Y. S. , Burgess, Janette K. , Brandsma, Corry‐Anke
D98. TARGETING THE SCAR: MECHANISMS AND TREATMENTS FOR FIBROTIC LUNG DISEASE | May 2, 2022 | Volume: No volume available | Issue: No issue available | Pages: A5317-A5317