Citations 2
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model
Aghababaie, Zahra , O’Grady, Gregory , Nisbet, Linley A., Modesto, Andre E. , Chan, Chih-Hsiang Alexander , Matthee, Ashton , Farrugia, Gianrico , Asirvatham, Samuel J. , Cheng, Leo K. , Farrugia, Gianrico , O'Grady, Gregory , Paskaranandavadivel, Niranchan , Cheng, Leo K , Angeli-Gordon, Timothy R , Asirvatham, Samuel J , Amirapu, Satya , Beyder, Arthur , Sands, Gregory B. , Paskaranandavadivel, Niranchan , Angeli, Timothy R.
American Journal of Physiology-Gastrointestinal and Liver Physiology | October 18, 2022 | Volume: 323 | Issue: 6 | Pages: G640-G652
Ablation has recently emerged as a tool for modulating gastric electrical activation and may hold interventional potential for disorders of gastric function. However, previous studies have been limited to the acute intraoperative setting. This study now presents the safety of gastric ablation after postsurgical recovery and healing. Localized electrical conduction blocks created by ablation remained after 2 wk of healing, and no perforation or other complications were observed over the postsurgical period.
Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model
Aghababaie, Zahra , Cheng, Leo K. , Paskaranandavadivel, Niranchan , Avci, Recep , Chan, Chih-Hsiang Alexander , Matthee, Ashton , Asirvatham, Samuel J. , Farrugia, Gianrico , O’Grady, Gregory , Angeli, Timothy R. , Farrugia, Gianrico , O'Grady, Gregory , Angeli-Gordon, Timothy R , Asirvatham, Samuel J , Paskaranandavadivel, Niranchan , Amirapu, Satya , Beyder, Arthur
American Journal of Physiology-Gastrointestinal and Liver Physiology | February 9, 2022 | Volume: 322 | Issue: 4 | Pages: G431-G445
This study presents gastric ablation as a novel tool for modulating gastric bioelectrical activation, including eliminating the normal gastric pacemaker site as well as abnormal ectopic pacemaker sites underlying gastric dysrhythmias. Targeted application of radiofrequency ablation was able to eliminate these pacemaker sites without disrupting surrounding conduction capability or tissue structure. Gastric ablation presents a powerful new research tool for modulating gastric electrical activation and may likely hold therapeutic potential for disorders of gastric function.