Citations 1
Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)
Hemsath, Jack R. , Liaci, A. Manuel , Rubin, Jeffrey D. , Parrett, Brian J. , Lu, Shao‐Chia , Turner, Mallory A., Chen, Christopher Y. , Cupelli, Karolina, Reddy, Vijay , Stehle, Thilo , Liszewski, M. Kathryn , Atkinson, John P. , Barry, Michael A. , Stehle, Thilo , Barry, Michael A , Nguyen, Tien Anh
Journal of Virology | November 17, 2021 | Volume: 96 | Issue: 3 | Pages: No page available
The human species D Ad26 is being investigated as a low-seroprevalence vector for oncolytic virotherapy and gene-based vaccination against HIV-1 and SARS-CoV-2. However, there is debate in the literature about its tropism and receptor utilization, which directly influence its efficiency for certain applications. This work was aimed at determining which receptor(s) this virus uses for infection and its role in virus biology, vaccine efficacy, and, importantly, vaccine safety.