Citations 3
Low antispike antibody levels correlate with poor outcomes in COVID‐19 breakthrough hospitalizations
Sanghavi, Devang , Bhakta, Shivang , Wadei, Hani M. , Bosch, Wendelyn , Cowart, Jennifer B. , Carter, Rickey E. , Shah, Sadia , Pollock, Benjamin D. , Neville, Matthew R., Oman, Sven P. , Speicher, Leigh L. , Siegel, Jason , Scindia, Ameya D., Matson, Mark W., Sanghavi, Devang K., Shah, Sadia Z. , Speicher, Leigh, Kunze, Katie L. , Carter, Rickey E , Wadei, Hani M , Pollock, Benjamin D , Libertin, Claudia R. , Johnson, Patrick W. , Franco, Pablo Moreno
Journal of Internal Medicine | February 23, 2022 | Volume: 292 | Issue: 1 | Pages: 127-135
AbstractBackgroundWhile COVID‐19 immunization programs attempted to reach targeted rates, cases rose significantly since the emergence of the delta variant. This retrospective cohort study describes the correlation between antispike antibodies and outcomes of hospitalized, breakthrough cases during the delta variant surge.MethodsAll patients with positive SARS‐CoV‐2 polymerase chain reaction hospitalized at Mayo Clinic Florida from 19 June 2021 to 11 November 2021 were considered for analysis. Cases were analyzed by vaccination status. Breakthrough cases were then analyzed by low and high antibody titers against SARS‐CoV‐2 spike protein, with a cut‐off value of ≥132 U/ml. Outcomes included hospital length of stay (LOS), need for intensive care unit (ICU), mechanical ventilation, and mortality. We used 1:1 nearest neighbor propensity score matching without replacement to assess for confounders.ResultsAmong 627 hospitalized patients with COVID‐19, vaccine breakthrough cases were older with more comorbidities compared to unvaccinated. After propensity score matching, the unvaccinated patients had higher mortality (27 [28.4%] vs. 12 [12.6%], p = 0.002) and LOS (7 [1.0–57.0] vs. 5 [1.0–31.0] days, p = 0.011). In breakthrough cases, low‐titer patients were more likely to be solid organ transplant recipients (16 [34.0%] vs. 9 [12.3%], p = 0.006), with higher need for ICU care (24 [51.1%] vs. 22 [11.0%], p = 0.034), longer hospital LOS (median 6 vs. 5 days, p = 0.013), and higher mortality (10 [21.3%] vs. 5 [6.8%], p = 0.025) than high‐titer patients.ConclusionsHospitalized breakthrough cases were more likely to have underlying risk factors than unvaccinated patients. Low‐spike antibody titers may serve as an indicator for poor prognosis in breakthrough cases admitted to the hospital.
559: MOLECULAR ADSORBENT RECIRCULATING SYSTEM (MARS): IS IT A RELIC OF MEDICAL HISTORY OR A LIFESAVER?
Hasan, Mohammed M. , Donepudi, Ashrita , Scindia, Ameya D., Giri, Abhishek R. , Santos, Christan, Lowman, Philip, Sanghavi, Devang , Franco, Pablo Moreno
Critical Care Medicine | December 16, 2021 | Volume: 50 | Issue: 1 | Pages: 271-271
Coronavirus Disease 2019 Vaccine-Breakthrough Infections Requiring Hospitalization in Mayo Clinic Florida Through August 2021
Bosch, Wendelyn , Cowart, Jennifer B. , Bhakta, Shivang , Carter, Rickey E. , Wadei, Hani M. , Shah, Sadia , Sanghavi, Devang , Pollock, Benjamin D. , Neville, Matthew R., Oman, Sven P. , Speicher, Leigh L. , Scindia, Ameya D., Matson, Mark W., Shah, Sadia Z. , Sanghavi, Devang K., Speicher, Leigh, Moreno Franco, Pablo, Carter, Rickey E , Wadei, Hani M , Pollock, Benjamin D , Franco, Pablo Moreno
Clinical Infectious Diseases | October 28, 2021 | Volume: 75 | Issue: 1 | Pages: e892-e894
Abstract We characterized coronavirus disease 2019 (COVID-19) breakthrough cases admitted to a single center in Florida. With the emergence of delta variant, an increased number of hospitalizations was seen due to breakthrough infections. These patients were older and more likely to have comorbidities. Preventive measures should be maintained even after vaccination.