Citations 2
Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study
Ulugut, Hülya , Samancı, Bedia , Illán‐Gala, Ignacio , Kuchcinski, Grégory , Leroy, Mélanie , Santillo, Alexander , Waldö, Maria Landqvist , Riedl, Lina , Stock, Jan Van den , Vandenbulcke, Mathieu , Ducharme, Simon , Pressman, Peter , Takada, Leonel Tadao , Diehl‐Schmid, Janine , Galimberti, Daniela , Barkhof, Frederik , Sturm, Virginia E. , Miyagawa, Toji , Whitwell, Jennifer L. , Rohrer, Jonathan D. , Gorno‐Tempini, Maria Luisa, Josephs, Keith A. , Warren, Jason D. , Rankin, Katherine P. , Group, International rtvFTD Working, Barkhof, Frederik , Rohrer, Jonathan D , Illán-Gala, Ignacio , Galimberti, Daniela , Bertoux, Maxime , Younes, Kyan , Montembeault, Maxime , Fumagalli, Giorgio , Thompson, J. C. , Kobylecki, Christopher , Englund, Elisabet , Vandenberghe, Rik , Laforce, Robert , Caramelli, Paulo , Souza, Leonardo Cruz de , Gurvit, Hakan I. , Hansson, Oskar , Pasquier, Florence , Miller, Bruce L. , Scheltens, Philip , Ossenkoppele, Rik , Flier, Wiesje M. van der , Fox, Nick C. , Boeve, Bradley F. , Gorno‐Tempini, Maria‐Luisa, Snowden, Julie S. , Pijnenburg, Yolande A.L. , Group, International rtvFTD Working
Alzheimer's & Dementia | July 10, 2024 | Volume: 20 | Issue: 8 | Pages: 5647-5661
Abstract INTRODUCTION Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word‐finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face‐recognition deficits (60%). Real‐life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real‐life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. Highlights This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
Radiomics Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke
Bretzner, Martin , Bonkhoff, Anna K. , Schirmer, Markus D. , Hong, Sung‐Min , Donahue, Kathleen, Etherton, Mark R. , Rist, Pamela M. , Nardin, Marco, Regenhardt, Robert W. , Leclerc, X. , Gautherot, Morgan , Wang, Clinton, Benavente, Oscar, Donatti, Amanda , Heitsch, Laura , Jiménez-Conde, Jordi , Kittner, Steven J. , McArdle, Patrick, Rolfs, Arndt , Schmidt, Reinhold, Sharma, Pankaj , Słowik, Agnieszka , Sousa, Alessandro Viana Oliveira e, Strbian, Daniel , Wassélius, Johan , Woo, Daniel , Worrall, Bradford B. , Maguire, Jane , Golland, Polina , Kuchcinski, Grégory , Rost, Natalia S. , Bretzner, Martin , Strbian, Daniel , Regenhardt, Robert W , Dalca, Adrian Vasile , Giese, Anne‐Katrin , Lopes, Renaud , Cole, John W. , Griessenauer, Christoph J. , Holmegaard, Lukas , Jood, Katarina , Lemmens, Robin , Levi, Christopher , McDonough, Caitrin W. , Meschia, James F. , Phuah, Chia‐Ling , Ropele, Stefan , Rosand, Jonathan M. , Roquer, Jaume , Rundek, Tatjana , Sacco, Ralph L. , Sousa, Alessandro Augusto Viana Oliveira e, Stanne, Tara M. , Tatlisumak, Turgut , Thijs, Vincent , Vagal, Achala , Wu, Ona , Zand, Ramin , Lindgren, Arne G. , Jern, Christina
No container title available | September 24, 2021 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract While chronological age is one of the most influential determinants of post-stroke outcomes, little is known of the impact of neuroimaging-derived biological brain age. We here first examine whether radiomics analysis of the texture of brain T2-FLAIR MRI images can be used to predict brain age in stroke patients. We then assess the clinical determinants of accelerated brain aging and, finally, its impact on post-stroke functional outcomes. Leveraging a multisite cohort of 4,163 ischemic stroke patients, we show that older-appearing patients have more hypertension, diabetes mellitus, prior strokes, and smoking history and are more likely to develop worse post-stroke outcomes than their younger-appearing counterparts. Our results strengthen the importance of preventive medicine for maintaining brain health in stroke patients as they age and suggest a novel methodology to capture previously undescribed prognostic information available on commonly acquired MRI sequences during routine stroke care.